Macrodantin and Anhedonia - a phase IV clinical study of FDA data

Summary:

Anhedonia is reported as a side effect among people who take Macrodantin (nitrofurantoin, macrocrystalline), especially for people who are female, 60+ old, also take Provera, and have Birth control.

The phase IV clinical study analyzes which people have Anhedonia when taking Macrodantin. It is created by eHealthMe based on reports of 3,567 people who have side effects when taking Macrodantin from the FDA, and is updated regularly.

What is Macrodantin?

Macrodantin has active ingredients of nitrofurantoin, macrocrystalline. It is often used in urinary tract infection. eHealthMe is studying from 3,755 Macrodantin users. Check the latest studies of Macrodantin.

What is Anhedonia?

Anhedonia (inability to experience pleasure from activities usually found enjoyable) is found to be associated with 1,506 drugs and 1,284 conditions by eHealthMe. Check the latest studies of Anhedonia.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 28, 2026

3,567 people reported to have side effects when taking Macrodantin.
Among them, 25 people (0.7%) have Anhedonia.

Among these 25 people:

What is the gender of people who have Anhedonia when taking Macrodantin? *

female: 86.36 %
male: 13.64 %

What is the age of people who have Anhedonia when taking Macrodantin? *

What are other drugs people take besides Macrodantin? *

What are other side effects people have besides Anhedonia? *

Stress And Anxiety: 24 people, 96.00%
Weakness: 18 people, 72.00%
Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 18 people, 72.00%
Hypoaesthesia (reduced sense of touch or sensation): 18 people, 72.00%
Nightmares (unpleasant dreams): 17 people, 68.00%
Tremor (trembling or shaking movements in one or more parts of your body): 17 people, 68.00%
Mood Swings (an extreme or rapid change in mood): 17 people, 68.00%
Sleep Disorder: 17 people, 68.00%
Intentional Self-Injury: 17 people, 68.00%
Decreased Interest: 17 people, 68.00%

What are the existing conditions these people have? *

Hiv Infection: 2 people, 8.00%
Chronic Kidney Disease: 2 people, 8.00%
Birth Control: 2 people, 8.00%
Toothaches (tooth pain): 1 person, 4.00%
Stress And Anxiety: 1 person, 4.00%
Quit Smoking: 1 person, 4.00%
Major Depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings): 1 person, 4.00%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 1 person, 4.00%
High Blood Cholesterol: 1 person, 4.00%
Generalized Anxiety Disorder (excessive, uncontrollable, unexplained and often irrational worry): 1 person, 4.00%

* Approximation only. Some reports may have incomplete information.

Do you take Macrodantin and have Anhedonia?

- Check whether Anhedonia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Macrodantin:

Macrodantin (3,755 reports)

Anhedonia treatments and more:

Anhedonia (51,944 reports)

How severe was Anhedonia and when was it recovered:

Anhedonia in Macrodantin

Expand to all the drugs that have ingredients of nitrofurantoin, macrocrystalline:

Anhedonia and drugs with ingredients of nitrofurantoin, macrocrystalline

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Macrodantin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Anhedonia:

Anhedonia (1,506 drugs)

Browse all the conditions that are associated with Anhedonia:

Anhedonia (1,284 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on nitrofurantoin, macrocrystalline (the active ingredients of Macrodantin) and Macrodantin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.