Macrodantin and Deep venous thrombosis - a phase IV clinical study of FDA data

Summary:

Deep venous thrombosis is reported as a side effect among people who take Macrodantin (nitrofurantoin, macrocrystalline), especially for people who are female, 60+ old, also take Percocet, and have Birth control.

The phase IV clinical study analyzes which people have Deep venous thrombosis when taking Macrodantin. It is created by eHealthMe based on reports of 3,567 people who have side effects when taking Macrodantin from the FDA, and is updated regularly.

What is Macrodantin?

Macrodantin has active ingredients of nitrofurantoin, macrocrystalline. It is often used in urinary tract infection. eHealthMe is studying from 3,755 Macrodantin users. Check the latest studies of Macrodantin.

What is Deep venous thrombosis?

Deep venous thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis) is found to be associated with 2,062 drugs and 2,968 conditions by eHealthMe. Check the latest studies of Deep venous thrombosis.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 26, 2026

3,567 people reported to have side effects when taking Macrodantin.
Among them, 26 people (0.73%) have Deep venous thrombosis.

Could Macrodantin cause Deep venous thrombosis?

Among these 26 people:

What is the gender of people who have Deep venous thrombosis when taking Macrodantin? *

female: 65.38 %
male: 34.62 %

What is the age of people who have Deep venous thrombosis when taking Macrodantin? *

What are other drugs people take besides Macrodantin? *

What are other side effects people have besides Deep venous thrombosis? *

Pulmonary Embolism (blockage of the main artery of the lung): 8 people, 30.77%
Fever: 7 people, 26.92%
Dyspnea (difficult or laboured breathing): 7 people, 26.92%
Pain: 7 people, 26.92%
Cellulitis (infection under the skin): 7 people, 26.92%
Stress And Anxiety: 6 people, 23.08%
Neurogenic Bladder (the normal function of the bladder is to store and empty urine in a coordinated, controlled fashion): 5 people, 19.23%
Muscle Aches (muscle pain): 5 people, 19.23%
Pain In Extremity: 5 people, 19.23%
Hypoaesthesia (reduced sense of touch or sensation): 5 people, 19.23%

What are the existing conditions these people have? *

Birth Control: 5 people, 19.23%
Constipation: 4 people, 15.38%
Drowsiness: 4 people, 15.38%
Muscle Spasms (muscle contraction): 4 people, 15.38%
Laxative Supportive Care: 4 people, 15.38%
High Blood Pressure: 2 people, 7.69%
Metastatic Renal Cell Carcinoma (spreadable kidney cell tumour): 2 people, 7.69%
Colorectal Cancer Metastatic (cancer of colon and rectal spreads to other parts): 2 people, 7.69%
Diabetes: 2 people, 7.69%
High Blood Cholesterol: 2 people, 7.69%

* Approximation only. Some reports may have incomplete information.

Do you take Macrodantin and have Deep venous thrombosis?

- Check whether Deep venous thrombosis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Macrodantin:

Macrodantin (3,755 reports)

Deep venous thrombosis treatments and more:

Deep venous thrombosis (130,305 reports)

How severe was Deep venous thrombosis and when was it recovered:

Deep venous thrombosis in Macrodantin

Expand to all the drugs that have ingredients of nitrofurantoin, macrocrystalline:

Deep venous thrombosis and drugs with ingredients of nitrofurantoin, macrocrystalline (129 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Macrodantin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Deep venous thrombosis:

Deep venous thrombosis (2,062 drugs)

Browse all the conditions that are associated with Deep venous thrombosis:

Deep venous thrombosis (2,968 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on nitrofurantoin, macrocrystalline (the active ingredients of Macrodantin) and Macrodantin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.