Macrodantin and Heart rate increased - a phase IV clinical study of FDA data

Summary:

Heart rate increased is reported as a side effect among people who take Macrodantin (nitrofurantoin, macrocrystalline), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Ventolin, and have Multiple sclerosis.

The phase IV clinical study analyzes which people have Heart rate increased when taking Macrodantin. It is created by eHealthMe based on reports of 3,567 people who have side effects when taking Macrodantin from the FDA, and is updated regularly.

What is Macrodantin?

Macrodantin has active ingredients of nitrofurantoin, macrocrystalline. It is often used in urinary tract infection. eHealthMe is studying from 3,755 Macrodantin users. Check the latest studies of Macrodantin.

What is Heart rate increased?

Heart rate increased is found to be associated with 2,387 drugs and 3,212 conditions by eHealthMe. Check the latest studies of Heart rate increased.

On Jul, 09, 2026

3,567 people reported to have side effects when taking Macrodantin.
Among them, 32 people (0.9%) have Heart rate increased.

Could Macrodantin cause Heart rate increased?

Among these 32 people:

How long have people been on Macrodantin when they have Heart rate increased? *

What is the gender of people who have Heart rate increased when taking Macrodantin? *

female: 90.32 %
male: 9.68 %

What is the age of people who have Heart rate increased when taking Macrodantin? *

What are other drugs people take besides Macrodantin? *

What are other side effects people have besides Heart rate increased? *

High Blood Pressure: 15 people, 46.88%
Nausea (feeling of having an urge to vomit): 13 people, 40.62%
Stress And Anxiety: 13 people, 40.62%
Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 11 people, 34.38%
Oral Discomfort (pain or irritation in mouth): 11 people, 34.38%
Oropharyngeal Pain: 11 people, 34.38%
Fatigue (feeling of tiredness): 10 people, 31.25%
Diarrhea: 9 people, 28.12%
Dizziness: 8 people, 25.00%
Headache (pain in head): 8 people, 25.00%

What are the existing conditions these people have? *

Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 8 people, 25.00%
Constipation: 6 people, 18.75%
Pain: 5 people, 15.62%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 5 people, 15.62%
High Blood Cholesterol: 3 people, 9.38%
Glaucoma (increased fluid pressure in the eye with vision loss): 2 people, 6.25%
Hypertonic Bladder (bladder-storage function that causes a sudden urge to urinate): 2 people, 6.25%
High Blood Pressure: 2 people, 6.25%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 2 people, 6.25%
Kidney Infection (Pyelonephritis): 1 person, 3.12%

* Approximation only. Some reports may have incomplete information.

Do you take Macrodantin and have Heart rate increased?

- Check whether Heart rate increased is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Macrodantin:

Macrodantin (3,755 reports)

Heart rate increased treatments and more:

Heart rate increased (126,750 reports)

How severe was Heart rate increased and when was it recovered:

Heart rate increased in Macrodantin

Expand to all the drugs that have ingredients of nitrofurantoin, macrocrystalline:

Heart rate increased and drugs with ingredients of nitrofurantoin, macrocrystalline (84 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Macrodantin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Heart rate increased:

Heart rate increased (2,387 drugs)

Browse all the conditions that are associated with Heart rate increased:

Heart rate increased (3,212 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on nitrofurantoin, macrocrystalline (the active ingredients of Macrodantin) and Macrodantin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.