Malarone and Heart rate increased - a phase IV clinical study of FDA data

Summary:

Heart rate increased is reported as a side effect among people who take Malarone (atovaquone; proguanil hydrochloride), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Fetzima, and have Asthma.

The phase IV clinical study analyzes which people have Heart rate increased when taking Malarone. It is created by eHealthMe based on reports of 2,660 people who have side effects when taking Malarone from the FDA, and is updated regularly.

What is Malarone?

Malarone has active ingredients of atovaquone; proguanil hydrochloride. It is often used in malaria. eHealthMe is studying from 3,098 Malarone users. Check the latest studies of Malarone.

What is Heart rate increased?

Heart rate increased is found to be associated with 2,384 drugs and 3,212 conditions by eHealthMe. Check the latest studies of Heart rate increased.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Jul, 31, 2026

2,660 people reported to have side effects when taking Malarone.
Among them, 19 people (0.71%) have Heart rate increased.

Could Malarone cause Heart rate increased?

Among these 19 people:

How long have people been on Malarone when they have Heart rate increased? *

What is the gender of people who have Heart rate increased when taking Malarone? *

female: 57.89 %
male: 42.11 %

What is the age of people who have Heart rate increased when taking Malarone? *

What are other drugs people take besides Malarone? *

Zithromax: 1 person, 5.26%
Restasis: 1 person, 5.26%
Progesterone: 1 person, 5.26%
Plaquenil: 1 person, 5.26%
Oxycontin: 1 person, 5.26%
Novocain: 1 person, 5.26%
Neurontin: 1 person, 5.26%
Mefloquine Hydrochloride: 1 person, 5.26%
Fish Oil: 1 person, 5.26%
Fetzima: 1 person, 5.26%

What are other side effects people have besides Heart rate increased? *

Dizziness: 7 people, 36.84%
Fatigue (feeling of tiredness): 7 people, 36.84%
Nausea And Vomiting: 4 people, 21.05%
Heart Palpitations (feelings or sensations that your heart is pounding or racing): 4 people, 21.05%
Rashes (redness): 3 people, 15.79%
Hypersensitivity: 3 people, 15.79%
Hypotension (abnormally low blood pressure): 3 people, 15.79%
Fever: 3 people, 15.79%
Feeling Abnormal: 3 people, 15.79%
Faeces Discolored: 3 people, 15.79%

What are the existing conditions these people have? *

Seasonal Allergy (allergic condition due to certain season): 1 person, 5.26%
Pulmonary Hypertension (increase in blood pressure in the lung artery): 1 person, 5.26%
Nervous System Disorder (a general class of medical conditions affecting the nervous system): 1 person, 5.26%
Major Depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings): 1 person, 5.26%
Lyme Disease (a bacterial infection that is spread to humans by infected ticks): 1 person, 5.26%
Asthma: 1 person, 5.26%

* Approximation only. Some reports may have incomplete information.

Do you take Malarone and have Heart rate increased?

- Check whether Heart rate increased is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Malarone:

Malarone (3,098 reports)

Heart rate increased treatments and more:

Heart rate increased (126,750 reports)

How severe was Heart rate increased and when was it recovered:

Heart rate increased in Malarone

Expand to all the drugs that have ingredients of atovaquone; proguanil hydrochloride:

Heart rate increased and drugs with ingredients of atovaquone; proguanil hydrochloride (27 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Malarone:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Heart rate increased:

Heart rate increased (2,384 drugs)

Browse all the conditions that are associated with Heart rate increased:

Heart rate increased (3,212 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on atovaquone; proguanil hydrochloride (the active ingredients of Malarone) and Malarone (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.