Maxzide and Mania aggravated - a phase IV clinical study of FDA data

Summary:

Mania aggravated is reported as a side effect among people who take Maxzide (hydrochlorothiazide; triamterene), especially for people who are female, 60+ old, also take Synthroid, and have Depression.

The phase IV clinical study analyzes which people have Mania aggravated when taking Maxzide. It is created by eHealthMe based on reports of 8,853 people who have side effects when taking Maxzide from the FDA, and is updated regularly.

What is Maxzide?

Maxzide has active ingredients of hydrochlorothiazide; triamterene. It is often used in high blood pressure. eHealthMe is studying from 9,152 Maxzide users. Check the latest studies of Maxzide.

What is Mania aggravated?

Mania aggravated (irritable mood) is found to be associated with 815 drugs and 375 conditions by eHealthMe. Check the latest studies of Mania aggravated.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 28, 2026

8,853 people reported to have side effects when taking Maxzide.
Among them, 16 people (0.18%) have Mania aggravated.

Among these 16 people:

What is the gender of people who have Mania aggravated when taking Maxzide? *

female: 56.25 %
male: 43.75 %

What is the age of people who have Mania aggravated when taking Maxzide? *

What are other drugs people take besides Maxzide? *

What are other side effects people have besides Mania aggravated? *

Agitation (state of anxiety or nervous excitement): 6 people, 37.50%
Diabetes: 5 people, 31.25%
Insomnia (sleeplessness): 5 people, 31.25%
Depression: 5 people, 31.25%
Stress And Anxiety: 4 people, 25.00%
Thinking Abnormal: 4 people, 25.00%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 3 people, 18.75%
Oedema Peripheral (superficial swelling): 3 people, 18.75%
Drowsiness: 3 people, 18.75%
Headache (pain in head): 3 people, 18.75%

What are the existing conditions these people have? *

Depression: 5 people, 31.25%
Restless Leg Syndrome (a powerful urge to move your legs): 2 people, 12.50%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 2 people, 12.50%
Stress And Anxiety: 1 person, 6.25%
Sleep Disorder: 1 person, 6.25%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 1 person, 6.25%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 1 person, 6.25%
Muscle Aches (muscle pain): 1 person, 6.25%
Mental Disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability): 1 person, 6.25%
High Blood Cholesterol: 1 person, 6.25%

* Approximation only. Some reports may have incomplete information.

Do you take Maxzide and have Mania aggravated?

- Check whether Mania aggravated is associated with a drug or a condition
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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Maxzide:

Maxzide (9,152 reports)

Mania aggravated treatments and more:

Mania aggravated (161 reports)

How severe was Mania aggravated and when was it recovered:

Mania aggravated in Maxzide

Expand to all the drugs that have ingredients of hydrochlorothiazide; triamterene:

Mania aggravated and drugs with ingredients of hydrochlorothiazide; triamterene (44 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Maxzide:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Mania aggravated:

Mania aggravated (815 drugs)

Browse all the conditions that are associated with Mania aggravated:

Mania aggravated (375 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on hydrochlorothiazide; triamterene (the active ingredients of Maxzide) and Maxzide (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.