Melphalan and Toxic encephalopathy - a phase IV clinical study of FDA data

Summary:

Toxic encephalopathy is reported as a side effect among people who take Melphalan (melphalan), especially for people who are male, 2-9 old, have been taking the drug for < 1 month also take Prograf, and have Bone marrow conditioning regimen.

The phase IV clinical study analyzes which people have Toxic encephalopathy when taking Melphalan. It is created by eHealthMe based on reports of 20,050 people who have side effects when taking Melphalan from the FDA, and is updated regularly.

What is Melphalan?

Melphalan has active ingredients of melphalan. eHealthMe is studying from 20,052 Melphalan users. Check the latest studies of Melphalan.

What is Toxic encephalopathy?

Toxic encephalopathy (a degenerative neurologic disorder caused by exposure to toxic substances) is found to be associated with 424 drugs and 615 conditions by eHealthMe. Check the latest studies of Toxic encephalopathy.

On Jul, 07, 2026

20,050 people reported to have side effects when taking Melphalan.
Among them, 15 people (0.07%) have Toxic encephalopathy.

Could Melphalan cause Toxic encephalopathy?

Among these 15 people:

How long have people been on Melphalan when they have Toxic encephalopathy? *

What is the gender of people who have Toxic encephalopathy when taking Melphalan? *

female: 35.71 %
male: 64.29 %

What is the age of people who have Toxic encephalopathy when taking Melphalan? *

What are other drugs people take besides Melphalan? *

What are other side effects people have besides Toxic encephalopathy? *

Viral Haemorrhagic Cystitis (lower urinary tract symptoms that include haematuria and irritative voiding symptoms): 2 people, 13.33%
Acute Graft Versus Host Disease (acute complication following an allogeneic tissue/blood transplant): 2 people, 13.33%
Hypertensive Encephalopathy (neurological dysfunction induced by malignant hypertension): 2 people, 13.33%
Chronic Graft Versus Host Disease (immune cells attack the host's body cells after transplant): 2 people, 13.33%
Post Transplant Distal Limb Syndrome: 2 people, 13.33%
Febrile Neutropenia (fever with reduced white blood cells): 2 people, 13.33%
Drug Ineffective: 2 people, 13.33%
Dizziness: 1 person, 6.67%
Graft Versus Host Disease In Liver (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the liver): 1 person, 6.67%
Gamma-Glutamyltransferase Increased: 1 person, 6.67%

What are the existing conditions these people have? *

Bone Marrow Conditioning Regimen: 4 people, 26.67%
Myelodysplastic Syndrome (a group of conditions that occur when the blood-forming cells in the bone marrow are damaged): 2 people, 13.33%
Multiple Myeloma (cancer of the plasma cells): 2 people, 13.33%
Graft Versus Host Disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body): 2 people, 13.33%
Fungal Infection: 2 people, 13.33%
Febrile Neutropenia (fever with reduced white blood cells): 2 people, 13.33%
Blood Pressure Diastolic Increased: 2 people, 13.33%
Behcet's Syndrome (involves inflammation of the blood vessels): 2 people, 13.33%
Aplastic Anemia: 2 people, 13.33%
Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts): 2 people, 13.33%

* Approximation only. Some reports may have incomplete information.

Do you take Melphalan and have Toxic encephalopathy?

- Check whether Toxic encephalopathy is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Melphalan:

Melphalan (20,052 reports)

Browse all side effects of Melphalan:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Toxic encephalopathy:

Toxic encephalopathy (424 drugs)

Browse all the conditions that are associated with Toxic encephalopathy:

Toxic encephalopathy (615 conditions)

Related publications that referenced our studies

Jeong SY, Jeon SJ, Kim YR, Choi SS, Kwak HS, "A Rare Case of Viagra Induced Toxic Encephalopathy", Investigative Magnetic Resonance Imaging, 2016 Sep .
Jeong SY, Jeon SJ, Kim YR, Choi SS, Kwak HS, "A Rare Case of Viagra Induced Toxic Encephalopathy", Investigative Magnetic Resonance Imaging, 2016 Sep .

How the study uses the data?

The study uses data from the FDA. It is based on melphalan (the active ingredients of Melphalan) and Melphalan (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.