Memantine hydrochloride and Death - a phase IV clinical study of FDA data

Summary:

Death is reported as a side effect among people who take Memantine hydrochloride (memantine hydrochloride), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Nuplazid, and have Dementia alzheimer's type.

The study is created by eHealthMe based on reports of 3,046 people who have side effects when taking Memantine hydrochloride from the FDA, and is updated regularly.

What is Memantine hydrochloride?

Memantine hydrochloride has active ingredients of memantine hydrochloride. eHealthMe is studying from 3,076 Memantine hydrochloride users. Check the latest studies of Memantine hydrochloride.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

3,046 people reported to have side effects when taking Memantine hydrochloride.
Among them, 90 people (2.95%) died.

Could Memantine hydrochloride cause Death?

Among these 90 people:

How long have people been on Memantine hydrochloride when they died? *

What is the gender of people who died when taking Memantine hydrochloride? *

female: 37.35 %
male: 62.65 %

What is the age of people who died when taking Memantine hydrochloride? *

What are other drugs people take besides Memantine hydrochloride? *

What are other side effects people have before they died? *

Fall: 7 people, 7.78%
Agitation (state of anxiety or nervous excitement): 6 people, 6.67%
Fatigue (feeling of tiredness): 5 people, 5.56%
Hip Fracture: 5 people, 5.56%
Confusional State: 5 people, 5.56%
Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 5 people, 5.56%
Pneumonia: 4 people, 4.44%
Drowsiness: 4 people, 4.44%
Weakness: 4 people, 4.44%
Aggression: 4 people, 4.44%

What are the existing conditions these people have? *

Dementia Alzheimer's Type (loss of mental ability with alzheimer's symptom): 11 people, 12.22%
Parkinson's Disease: 10 people, 11.11%
Hallucinations (sensations that appear real but are created by your mind): 6 people, 6.67%
Delusion (a false belief or opinion): 5 people, 5.56%
Dementia (madness): 5 people, 5.56%
Hyperkalemia (damage to or disease of the kidney): 4 people, 4.44%
Stress And Anxiety: 4 people, 4.44%
Presenile Dementia (memory disorders starts in the 40s or 50s): 3 people, 3.33%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 3 people, 3.33%
High Blood Cholesterol: 3 people, 3.33%

* Approximation only. Some reports may have incomplete information.

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Memantine hydrochloride:

Memantine hydrochloride (3,076 reports)

Expand to all the drugs that have ingredients of memantine hydrochloride:

Death and drugs with ingredients of memantine hydrochloride (878 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Memantine hydrochloride:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Death:

Death (3,107 drugs)

Browse all the conditions that are associated with Death:

Death (3,686 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on memantine hydrochloride (the active ingredients of Memantine hydrochloride) and Memantine hydrochloride (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.