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Mercaptopurine and Hypocalcaemia - a phase IV clinical study of FDA data

Summary:

Hypocalcaemia is reported as a side effect among people who take Mercaptopurine (mercaptopurine), especially for people who are female, 10-19 old, have been taking the drug for < 1 month also take Cyclophosphamide, and have Acute lymphocytic leukemia (all).

The phase IV clinical study analyzes which people have Hypocalcaemia when taking Mercaptopurine. It is created by eHealthMe based on reports of 22,744 people who have side effects when taking Mercaptopurine from the FDA, and is updated regularly.

What is Mercaptopurine?

Mercaptopurine has active ingredients of mercaptopurine. It is often used in crohn's disease. eHealthMe is studying from 23,013 Mercaptopurine users. Check the latest studies of Mercaptopurine.

What is Hypocalcaemia?

Hypocalcaemia (levels of calcium in blood serum are abnormally low) is found to be associated with 1,193 drugs and 1,302 conditions by eHealthMe. Check the latest studies of Hypocalcaemia.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

22,744 people reported to have side effects when taking Mercaptopurine.
Among them, 48 people (0.21%) have Hypocalcaemia.

Could Mercaptopurine cause Hypocalcaemia?

Among these 48 people:

How long have people been on Mercaptopurine when they have Hypocalcaemia? *

  • < 1 month: 66.67 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 33.33 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

What is the gender of people who have Hypocalcaemia when taking Mercaptopurine? *

  • female: 53.19 %
  • male: 46.81 %

What is the age of people who have Hypocalcaemia when taking Mercaptopurine? *

  • 0-1: 2.27 %
  • 2-9: 31.82 %
  • 10-19: 43.18 %
  • 20-29: 2.27 %
  • 30-39: 9.09 %
  • 40-49: 0.0 %
  • 50-59: 9.09 %
  • 60+: 2.27 %

What are other drugs people take besides Mercaptopurine? *

  1. Methotrexate: 17 people, 35.42%
  2. Cyclophosphamide: 17 people, 35.42%
  3. Cytarabine: 15 people, 31.25%
  4. Prednisone: 10 people, 20.83%
  5. Bactrim: 9 people, 18.75%
  6. Oncaspar: 9 people, 18.75%
  7. Etoposide: 8 people, 16.67%
  8. Vancomycin: 7 people, 14.58%
  9. Thioguanine: 6 people, 12.50%
  10. Glivec: 5 people, 10.42%

What are other side effects people have besides Hypocalcaemia? *

  1. Fever: 25 people, 52.08%
  2. Hypoalbuminaemia (levels of albumin in blood serum are abnormally low): 20 people, 41.67%
  3. Hypokalemia (low potassium): 19 people, 39.58%
  4. Hypophosphataemia (electrolyte disturbance in which there is an abnormally low level of phosphate in the blood): 16 people, 33.33%
  5. Alanine Aminotransferase Increased: 15 people, 31.25%
  6. Aspartate Aminotransferase Increased: 14 people, 29.17%
  7. Anaemia (lack of blood): 14 people, 29.17%
  8. Hyperglycemia (high blood sugar): 14 people, 29.17%
  9. Hypotension (abnormally low blood pressure): 13 people, 27.08%
  10. Thrombocytopenia (decrease of platelets in blood): 12 people, 25.00%

What are the existing conditions these people have? *

  1. Acute Lymphocytic Leukemia (All) (cancer of the white blood cells characterized by excess lymphoblasts): 21 people, 43.75%
  2. B Precursor Type Acute Leukaemia (lymphoid cancer): 7 people, 14.58%
  3. Hypercalcaemia (elevated calcium (ca+) level in the blood): 4 people, 8.33%
  4. T-Cell Type Acute Leukaemia (a form of cancer of the white blood cells): 3 people, 6.25%
  5. Indigestion: 3 people, 6.25%
  6. Febrile Neutropenia (fever with reduced white blood cells): 2 people, 4.17%
  7. Seizures (abnormal excessive or synchronous neuronal activity in the brain): 2 people, 4.17%
  8. Immunodeficiency Disorders: 2 people, 4.17%
  9. Precursor T-Lymphoblastic Lymphoma/leukaemia (precursor b-cell cancer): 2 people, 4.17%
  10. Langerhans' Cell Histiocytosis: 1 person, 2.08%

* Approximation only. Some reports may have incomplete information.

Do you take Mercaptopurine and have Hypocalcaemia?

- Check whether Hypocalcaemia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Mercaptopurine:

Hypocalcaemia treatments and more:

How severe was Hypocalcaemia and when was it recovered:

Expand to all the drugs that have ingredients of mercaptopurine:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Mercaptopurine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hypocalcaemia:

Browse all the conditions that are associated with Hypocalcaemia:

How the study uses the data?

The study uses data from the FDA. It is based on mercaptopurine (the active ingredients of Mercaptopurine) and Mercaptopurine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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