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Metaxalone and Hyponatremia - a phase IV clinical study of FDA data

Summary:

Hyponatremia is reported as a side effect among people who take Metaxalone (metaxalone), especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months also take Benadryl, and have Parkinson's disease.

The phase IV clinical study analyzes which people have Hyponatremia when taking Metaxalone. It is created by eHealthMe based on reports of 4,277 people who have side effects when taking Metaxalone from the FDA, and is updated regularly.

What is Metaxalone?

Metaxalone has active ingredients of metaxalone. It is often used in back pain. eHealthMe is studying from 4,452 Metaxalone users. Check the latest studies of Metaxalone.

What is Hyponatremia?

Hyponatremia (abnormally low level of sodium in the blood; associated with dehydration) is found to be associated with 1,941 drugs and 2,277 conditions by eHealthMe. Check the latest studies of Hyponatremia.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

4,277 people reported to have side effects when taking Metaxalone.
Among them, 20 people (0.47%) have Hyponatremia.

Could Metaxalone cause Hyponatremia?

Among these 20 people:

How long have people been on Metaxalone when they have Hyponatremia? *

  • < 1 month: 0.0 %
  • 1 - 6 months: 100 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

What is the gender of people who have Hyponatremia when taking Metaxalone? *

  • female: 90 %
  • male: 10 %

What is the age of people who have Hyponatremia when taking Metaxalone? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 25 %
  • 40-49: 0.0 %
  • 50-59: 0.0 %
  • 60+: 75 %

What are other drugs people take besides Metaxalone? *

  1. Skelaxin: 16 people, 80.00%
  2. Benadryl: 16 people, 80.00%
  3. Meloxicam: 12 people, 60.00%
  4. Omeprazole: 10 people, 50.00%
  5. Sulfatrim-Ds: 10 people, 50.00%
  6. Glucosamine Sulfate: 10 people, 50.00%
  7. Folic Acid: 10 people, 50.00%
  8. Reclast: 10 people, 50.00%
  9. Hydrocodone Bitartrate And Acetaminophen: 10 people, 50.00%
  10. Aspirin: 10 people, 50.00%

What are other side effects people have besides Hyponatremia? *

  1. Stress And Anxiety: 16 people, 80.00%
  2. Pain: 15 people, 75.00%
  3. Nausea (feeling of having an urge to vomit): 15 people, 75.00%
  4. Constipation: 10 people, 50.00%
  5. Urination - Painful: 10 people, 50.00%
  6. Adrenal Insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids): 10 people, 50.00%
  7. Nausea And Vomiting: 9 people, 45.00%
  8. Weight Decreased: 8 people, 40.00%
  9. Nervousness: 8 people, 40.00%
  10. Confusional State: 8 people, 40.00%

What are the existing conditions these people have? *

  1. Parkinson's Disease: 10 people, 50.00%
  2. Constipation: 8 people, 40.00%
  3. Pain: 8 people, 40.00%
  4. Urinary Tract Infection: 7 people, 35.00%
  5. Nausea (feeling of having an urge to vomit): 7 people, 35.00%
  6. Bladder Disorder: 7 people, 35.00%
  7. Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it): 7 people, 35.00%
  8. Dry Eyes (lack of adequate tears): 7 people, 35.00%
  9. Dry Mouth: 7 people, 35.00%
  10. Insomnia (sleeplessness): 7 people, 35.00%

* Approximation only. Some reports may have incomplete information.

Do you take Metaxalone and have Hyponatremia?

- Check whether Hyponatremia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Metaxalone:

Hyponatremia treatments and more:

How severe was Hyponatremia and when was it recovered:

Expand to all the drugs that have ingredients of metaxalone:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Metaxalone:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hyponatremia:

Browse all the conditions that are associated with Hyponatremia:

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on metaxalone (the active ingredients of Metaxalone) and Metaxalone (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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