Metaxalone and Musculoskeletal pain - a phase IV clinical study of FDA data

Summary:

Musculoskeletal pain is reported as a side effect among people who take Metaxalone (metaxalone), especially for people who are male, 60+ old, also take Zantac, and have Pain.

The phase IV clinical study analyzes which people have Musculoskeletal pain when taking Metaxalone. It is created by eHealthMe based on reports of 4,277 people who have side effects when taking Metaxalone from the FDA, and is updated regularly.

What is Metaxalone?

Metaxalone has active ingredients of metaxalone. It is often used in back pain. eHealthMe is studying from 4,452 Metaxalone users. Check the latest studies of Metaxalone.

What is Musculoskeletal pain?

Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves) is found to be associated with 1,877 drugs and 1,827 conditions by eHealthMe. Check the latest studies of Musculoskeletal pain.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

4,277 people reported to have side effects when taking Metaxalone.
Among them, 24 people (0.56%) have Musculoskeletal pain.

Could Metaxalone cause Musculoskeletal pain?

Among these 24 people:

What is the gender of people who have Musculoskeletal pain when taking Metaxalone? *

female: 50 %
male: 50 %

What is the age of people who have Musculoskeletal pain when taking Metaxalone? *

What are other drugs people take besides Metaxalone? *

What are other side effects people have besides Musculoskeletal pain? *

Joint Pain: 10 people, 41.67%
Pain In Extremity: 7 people, 29.17%
Fall: 7 people, 29.17%
Scoliosis (a medical condition in which a person's spine is curved from side to side): 6 people, 25.00%
Intervertebral Disc Degeneration (spinal disc degeneration): 5 people, 20.83%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 5 people, 20.83%
Body Height Decreased: 5 people, 20.83%
Cellulitis (infection under the skin): 4 people, 16.67%
Arthropathy: 4 people, 16.67%
Swelling: 4 people, 16.67%

What are the existing conditions these people have? *

Pain: 10 people, 41.67%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 5 people, 20.83%
Joint Pain: 4 people, 16.67%
Fluid Retention (an abnormal accumulation of fluid in the blood): 4 people, 16.67%
Growth Hormone Deficiency: 4 people, 16.67%
Haemorrhage (bleeding): 4 people, 16.67%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 4 people, 16.67%
Breakthrough Pain: 4 people, 16.67%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 16.67%
Hypopituitarism (diminished hormone secretion by the pituitary gland, causing dwarfism in children and premature aging in adults): 3 people, 12.50%

* Approximation only. Some reports may have incomplete information.

Do you take Metaxalone and have Musculoskeletal pain?

- Check whether Musculoskeletal pain is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Metaxalone:

Metaxalone (4,452 reports)

Browse all side effects of Metaxalone:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Musculoskeletal pain:

Musculoskeletal pain (1,877 drugs)

Browse all the conditions that are associated with Musculoskeletal pain:

Musculoskeletal pain (1,827 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on metaxalone (the active ingredients of Metaxalone) and Metaxalone (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.