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Metformin hydrochloride and Hypoglycaemic encephalopathy - a phase IV clinical study of FDA data

Summary:

Hypoglycaemic encephalopathy is reported as a side effect among people who take Metformin hydrochloride (metformin hydrochloride), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Lantus, and have Blood glucose increased.

The phase IV clinical study analyzes which people have Hypoglycaemic encephalopathy when taking Metformin hydrochloride. It is created by eHealthMe based on reports of 54,785 people who have side effects when taking Metformin hydrochloride from the FDA, and is updated regularly.

What is Metformin hydrochloride?

Metformin hydrochloride has active ingredients of metformin hydrochloride. It is often used in diabetes. eHealthMe is studying from 58,646 Metformin hydrochloride users. Check the latest studies of Metformin hydrochloride.

What is Hypoglycaemic encephalopathy?

Hypoglycaemic encephalopathy (brain damage due to low blood sugar) is found to be associated with 35 drugs and 136 conditions by eHealthMe. Check the latest studies of Hypoglycaemic encephalopathy.

On Jul, 06, 2026

54,785 people reported to have side effects when taking Metformin hydrochloride.
Among them, 26 people (0.05%) have Hypoglycaemic encephalopathy.

Could Metformin hydrochloride cause Hypoglycaemic encephalopathy?

Among these 26 people:

How long have people been on Metformin hydrochloride when they have Hypoglycaemic encephalopathy? *

  • < 1 month: 25 %
  • 1 - 6 months: 25 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 25 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 25 %

What is the gender of people who have Hypoglycaemic encephalopathy when taking Metformin hydrochloride? *

  • female: 56.52 %
  • male: 43.48 %

What is the age of people who have Hypoglycaemic encephalopathy when taking Metformin hydrochloride? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 21.74 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 8.7 %
  • 50-59: 0.0 %
  • 60+: 69.57 %

What are other drugs people take besides Metformin hydrochloride? *

  1. Lantus: 3 people, 11.54%
  2. Tagamet: 2 people, 7.69%
  3. Allegra: 2 people, 7.69%
  4. Livostin: 2 people, 7.69%
  5. Desyrel: 2 people, 7.69%
  6. Januvia: 2 people, 7.69%
  7. Ryzodeg 70/30: 2 people, 7.69%
  8. Gliclazide: 1 person, 3.85%
  9. Amaryl: 1 person, 3.85%
  10. Famotidine: 1 person, 3.85%

What are other side effects people have besides Hypoglycaemic encephalopathy? *

  1. Hypoglycemia (low blood sugar): 8 people, 30.77%
  2. Hypoglycaemic Coma (coma due to deficiency of glucose in the bloodstream): 5 people, 19.23%
  3. Suicide Attempt: 4 people, 15.38%
  4. Pneumonia Aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree): 4 people, 15.38%
  5. Overdose: 3 people, 11.54%
  6. Loss Of Consciousness: 3 people, 11.54%
  7. Consciousness - Decreased: 3 people, 11.54%
  8. Fever: 2 people, 7.69%
  9. Drowsiness: 2 people, 7.69%
  10. Stupor (lack of critical cognitive function and level of consciousness): 2 people, 7.69%

What are the existing conditions these people have? *

  1. Blood Glucose Increased: 3 people, 11.54%
  2. Periarthritis (inflammation of the external coats of an artery and of the tissues around the artery): 2 people, 7.69%
  3. Panic Disorder: 2 people, 7.69%
  4. Nasopharyngitis (inflammation of the nasopharynx): 2 people, 7.69%
  5. Insomnia (sleeplessness): 2 people, 7.69%
  6. Gastritis - Chronic (long lasting inflammation of stomach): 2 people, 7.69%
  7. Dry Eyes (lack of adequate tears): 2 people, 7.69%
  8. Conjunctivitis Bacterial (infection of conjunctiva by bacteria): 2 people, 7.69%
  9. Conjunctivitis Allergic (inflammation of the conjunctiva due to allergy): 2 people, 7.69%
  10. Chest Pain: 2 people, 7.69%

* Approximation only. Some reports may have incomplete information.

Do you take Metformin hydrochloride and have Hypoglycaemic encephalopathy?

- Check whether Hypoglycaemic encephalopathy is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Metformin hydrochloride:

Hypoglycaemic encephalopathy treatments and more:

How severe was Hypoglycaemic encephalopathy and when was it recovered:

Expand to all the drugs that have ingredients of metformin hydrochloride:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Metformin hydrochloride:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hypoglycaemic encephalopathy:

Browse all the conditions that are associated with Hypoglycaemic encephalopathy:

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on metformin hydrochloride (the active ingredients of Metformin hydrochloride) and Metformin hydrochloride (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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