Metformin hydrochloride and Initial insomnia - a phase IV clinical study of FDA data

Summary:

Initial insomnia is reported as a side effect among people who take Metformin hydrochloride (metformin hydrochloride), especially for people who are female, 40-49 old, have been taking the drug for < 1 month also take Aspirin, and have Primary progressive multiple sclerosis.

The phase IV clinical study analyzes which people have Initial insomnia when taking Metformin hydrochloride. It is created by eHealthMe based on reports of 54,785 people who have side effects when taking Metformin hydrochloride from the FDA, and is updated regularly.

What is Metformin hydrochloride?

Metformin hydrochloride has active ingredients of metformin hydrochloride. It is often used in diabetes. eHealthMe is studying from 58,646 Metformin hydrochloride users. Check the latest studies of Metformin hydrochloride.

What is Initial insomnia?

Initial insomnia (feeling of inadequate or poor-quality sleep) is found to be associated with 715 drugs and 689 conditions by eHealthMe. Check the latest studies of Initial insomnia.

On Aug, 01, 2026

54,785 people reported to have side effects when taking Metformin hydrochloride.
Among them, 40 people (0.07%) have Initial insomnia.

Could Metformin hydrochloride cause Initial insomnia?

Among these 40 people:

How long have people been on Metformin hydrochloride when they have Initial insomnia? *

What is the gender of people who have Initial insomnia when taking Metformin hydrochloride? *

female: 75 %
male: 25 %

What is the age of people who have Initial insomnia when taking Metformin hydrochloride? *

What are other drugs people take besides Metformin hydrochloride? *

What are other side effects people have besides Initial insomnia? *

Fatigue (feeling of tiredness): 26 people, 65.00%
Hypoaesthesia (reduced sense of touch or sensation): 18 people, 45.00%
Nausea (feeling of having an urge to vomit): 17 people, 42.50%
Headache (pain in head): 17 people, 42.50%
Gait Disturbance: 16 people, 40.00%
Drug Ineffective: 15 people, 37.50%
Muscle Spasms (muscle contraction): 15 people, 37.50%
Stress And Anxiety: 15 people, 37.50%
Dizziness: 14 people, 35.00%
Vision Blurred: 13 people, 32.50%

What are the existing conditions these people have? *

Primary Progressive Multiple Sclerosis (primary progressive inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 10 people, 25.00%
Dermatitis Atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder): 4 people, 10.00%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 4 people, 10.00%
Breast Cancer Female: 3 people, 7.50%
Restless Leg Syndrome (a powerful urge to move your legs): 3 people, 7.50%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 3 people, 7.50%
Dry Eyes (lack of adequate tears): 2 people, 5.00%
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters): 2 people, 5.00%
Fibromyalgia (a long-term condition which causes pain all over the body): 2 people, 5.00%
Bronchial Hyperreactivity: 2 people, 5.00%

* Approximation only. Some reports may have incomplete information.

Do you take Metformin hydrochloride and have Initial insomnia?

- Check whether Initial insomnia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Metformin hydrochloride:

Metformin hydrochloride (58,646 reports)

Initial insomnia treatments and more:

Initial insomnia (12,139 reports)

Browse all side effects of Metformin hydrochloride:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Initial insomnia:

Initial insomnia (715 drugs)

Browse all the conditions that are associated with Initial insomnia:

Initial insomnia (689 conditions)

Related publications that referenced our studies

T.Audi Yanto, I.Huang, F.Nathania Kosasih, NP Hardjo Lugito, "Nightmare and Abnormal Dreams: Rare Side Effects of Metformin?", Case Reports in Endocrinology, 2018 Jan .
Al-Hamdy RA, "Assessment of electrolytes and HbA1c in type 2 diabetic patients using metformin and evaluation of guidelines obedience regarding renal impairment", J.Thi-Qar Sci., 2015 Jan .
Wiwanitkit S, Wiwanitkit V, "Metformin and sleep disorders", Indian journal of endocrinology and metabolism, 2012 Jan .
T.Audi Yanto, I.Huang, F.Nathania Kosasih, NP Hardjo Lugito, "Nightmare and Abnormal Dreams: Rare Side Effects of Metformin?", Case Reports in Endocrinology, 2018 Jan .
Al-Hamdy RA, "Assessment of electrolytes and HbA1c in type 2 diabetic patients using metformin and evaluation of guidelines obedience regarding renal impairment", J.Thi-Qar Sci., 2015 Jan .
Wiwanitkit S, Wiwanitkit V, "Metformin and sleep disorders", Indian journal of endocrinology and metabolism, 2012 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on metformin hydrochloride (the active ingredients of Metformin hydrochloride) and Metformin hydrochloride (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.