Metformin and Adrenal insufficiency - a phase IV clinical study of FDA data

Summary:

Adrenal insufficiency is reported as a side effect among people who take Metformin (metformin hydrochloride), especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months also take Prednisone, and have Rheumatoid arthritis.

The phase IV clinical study analyzes which people have Adrenal insufficiency when taking Metformin. It is created by eHealthMe based on reports of 453,860 people who have side effects when taking Metformin from the FDA, and is updated regularly.

What is Metformin?

Metformin has active ingredients of metformin hydrochloride. It is often used in diabetes. eHealthMe is studying from 465,354 Metformin users. Check the latest studies of Metformin.

What is Adrenal insufficiency?

Adrenal insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids) is found to be associated with 967 drugs and 1,093 conditions by eHealthMe. Check the latest studies of Adrenal insufficiency.

On Jul, 20, 2026

453,860 people reported to have side effects when taking Metformin.
Among them, 367 people (0.08%) have Adrenal insufficiency.

Could Metformin cause Adrenal insufficiency?

Among these 367 people:

How long have people been on Metformin when they have Adrenal insufficiency? *

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What is the gender of people who have Adrenal insufficiency when taking Metformin? *

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What is the age of people who have Adrenal insufficiency when taking Metformin? *

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* Approximation only. Some reports may have incomplete information.

Do you take Metformin and have Adrenal insufficiency?

- Check whether Adrenal insufficiency is associated with a drug or a condition
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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Metformin:

Metformin (465,354 reports)

Adrenal insufficiency treatments and more:

Adrenal insufficiency (16,569 reports)

How severe was Adrenal insufficiency and when was it recovered:

Adrenal insufficiency in Metformin

Expand to all the drugs that have ingredients of metformin hydrochloride:

Adrenal insufficiency and drugs with ingredients of metformin hydrochloride (411 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Metformin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Adrenal insufficiency:

Adrenal insufficiency (967 drugs)

Browse all the conditions that are associated with Adrenal insufficiency:

Adrenal insufficiency (1,093 conditions)

Related publications that referenced our studies

T.Audi Yanto, I.Huang, F.Nathania Kosasih, NP Hardjo Lugito, "Nightmare and Abnormal Dreams: Rare Side Effects of Metformin?", Case Reports in Endocrinology, 2018 Jan .
Al-Hamdy RA, "Assessment of electrolytes and HbA1c in type 2 diabetic patients using metformin and evaluation of guidelines obedience regarding renal impairment", J.Thi-Qar Sci., 2015 Jan .
Wiwanitkit S, Wiwanitkit V, "Metformin and sleep disorders", Indian journal of endocrinology and metabolism, 2012 Jan .
T.Audi Yanto, I.Huang, F.Nathania Kosasih, NP Hardjo Lugito, "Nightmare and Abnormal Dreams: Rare Side Effects of Metformin?", Case Reports in Endocrinology, 2018 Jan .
Al-Hamdy RA, "Assessment of electrolytes and HbA1c in type 2 diabetic patients using metformin and evaluation of guidelines obedience regarding renal impairment", J.Thi-Qar Sci., 2015 Jan .
Wiwanitkit S, Wiwanitkit V, "Metformin and sleep disorders", Indian journal of endocrinology and metabolism, 2012 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on metformin hydrochloride (the active ingredients of Metformin) and Metformin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.