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Metformin and Aortic valve calcification - a phase IV clinical study of FDA data

Summary:

Aortic valve calcification is reported as a side effect among people who take Metformin (metformin hydrochloride), especially for people who are female, 60+ old, also take Entresto, and have High blood cholesterol.

The phase IV clinical study analyzes which people have Aortic valve calcification when taking Metformin. It is created by eHealthMe based on reports of 453,860 people who have side effects when taking Metformin from the FDA, and is updated regularly.

What is Metformin?

Metformin has active ingredients of metformin hydrochloride. It is often used in diabetes. eHealthMe is studying from 465,358 Metformin users. Check the latest studies of Metformin.

What is Aortic valve calcification?

Aortic valve calcification is found to be associated with 168 drugs and 281 conditions by eHealthMe. Check the latest studies of Aortic valve calcification.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

453,860 people reported to have side effects when taking Metformin.
Among them, 34 people (0.01%) have Aortic valve calcification.

Could Metformin cause Aortic valve calcification?

Among these 34 people:

What is the gender of people who have Aortic valve calcification when taking Metformin? *

  • female: 63.64 %
  • male: 36.36 %

What is the age of people who have Aortic valve calcification when taking Metformin? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 6.67 %
  • 50-59: 0.0 %
  • 60+: 93.33 %

What are other drugs people take besides Metformin? *

  1. Entresto: 13 people, 38.24%
  2. Rivaroxaban: 12 people, 35.29%
  3. Aspirin: 11 people, 32.35%
  4. Glyburide: 10 people, 29.41%
  5. Sitagliptin: 10 people, 29.41%
  6. Digoxin: 8 people, 23.53%
  7. Lisinopril: 7 people, 20.59%
  8. Lasix: 7 people, 20.59%
  9. Ibuprofen: 6 people, 17.65%
  10. Nexium: 6 people, 17.65%

What are other side effects people have besides Aortic valve calcification? *

  1. Tricuspid Valve Incompetence (inefficient heart valve): 20 people, 58.82%
  2. Oedema Peripheral (superficial swelling): 18 people, 52.94%
  3. Fatigue (feeling of tiredness): 18 people, 52.94%
  4. Mitral Valve Incompetence (inefficient heart valve): 17 people, 50.00%
  5. Cough: 17 people, 50.00%
  6. Aortic Stenosis (obstruction to the outflow of blood from the left ventricle into the aorta): 16 people, 47.06%
  7. Left Ventricular Dysfunction: 15 people, 44.12%
  8. Cardiac Murmur (an heart sound in valve abnormality): 14 people, 41.18%
  9. Cardiac Failure: 14 people, 41.18%
  10. Pulmonary Hypertension (increase in blood pressure in the lung artery): 14 people, 41.18%

What are the existing conditions these people have? *

  1. High Blood Cholesterol: 6 people, 17.65%
  2. Human Seminal Plasma Hypersensitivity: 5 people, 14.71%
  3. Chronic Myeloid Leukaemia (long lasting type of cancer that starts in the blood-forming cells of the bone marrow and invades the blood): 5 people, 14.71%
  4. Osteoporosis Post-Menopausal (weak bone with possibility to break after stopped menstrual cycles): 5 people, 14.71%
  5. Muscle Spasms (muscle contraction): 5 people, 14.71%
  6. Joint Swelling: 2 people, 5.88%
  7. Back Pain: 2 people, 5.88%
  8. Cardiac Disorder: 2 people, 5.88%
  9. Fibrocystic Breast Disease (a condition causing breast pain, cysts, and noncancerous breast lumps, affects many women): 2 people, 5.88%
  10. Fungal Infection: 2 people, 5.88%

* Approximation only. Some reports may have incomplete information.

Do you take Metformin and have Aortic valve calcification?

- Check whether Aortic valve calcification is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Metformin:

Aortic valve calcification treatments and more:

How severe was Aortic valve calcification and when was it recovered:

Expand to all the drugs that have ingredients of metformin hydrochloride:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Metformin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Aortic valve calcification:

Browse all the conditions that are associated with Aortic valve calcification:

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on metformin hydrochloride (the active ingredients of Metformin) and Metformin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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