1. Home
  2. Analysis
  3. Metformin
  4. Application-site-irritation

Metformin and Application site irritation - a phase IV clinical study of FDA data

Summary:

Application site irritation is reported as a side effect among people who take Metformin (metformin hydrochloride), especially for people who are female, 60+ old, also take Lisinopril, and have High blood pressure.

The phase IV clinical study analyzes which people have Application site irritation when taking Metformin. It is created by eHealthMe based on reports of 453,860 people who have side effects when taking Metformin from the FDA, and is updated regularly.

What is Metformin?

Metformin has active ingredients of metformin hydrochloride. It is often used in diabetes. eHealthMe is studying from 465,358 Metformin users. Check the latest studies of Metformin.

What is Application site irritation?

Application site irritation is found to be associated with 387 drugs and 702 conditions by eHealthMe. Check the latest studies of Application site irritation.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

453,860 people reported to have side effects when taking Metformin.
Among them, 95 people (0.02%) have Application site irritation.

Could Metformin cause Application site irritation?

Among these 95 people:

What is the gender of people who have Application site irritation when taking Metformin? *

  • female: 67.74 %
  • male: 32.26 %

What is the age of people who have Application site irritation when taking Metformin? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 3.57 %
  • 40-49: 10.71 %
  • 50-59: 28.57 %
  • 60+: 57.14 %

What are other drugs people take besides Metformin? *

  1. Lisinopril: 14 people, 14.74%
  2. Lipitor: 11 people, 11.58%
  3. Aspirin: 10 people, 10.53%
  4. Gabapentin: 8 people, 8.42%
  5. Vitamin D3: 7 people, 7.37%
  6. Biotin: 7 people, 7.37%
  7. Catapres-Tts-1: 7 people, 7.37%
  8. Exelon: 6 people, 6.32%
  9. Cymbalta: 6 people, 6.32%
  10. Synthroid: 6 people, 6.32%

What are other side effects people have besides Application site irritation? *

  1. Application Site Erythema (redness of the skin at application site): 40 people, 42.11%
  2. Application Site Pruritus (application site severe itching of the skin): 30 people, 31.58%
  3. Application Site Pain: 23 people, 24.21%
  4. Drug Ineffective: 9 people, 9.47%
  5. High Blood Pressure: 7 people, 7.37%
  6. Application Site Vesicles (small bubble within a cell at application site): 7 people, 7.37%
  7. Application Site Rash: 7 people, 7.37%
  8. Agitation (state of anxiety or nervous excitement): 6 people, 6.32%
  9. Application Site Burn: 6 people, 6.32%
  10. Drug Effect Decreased: 6 people, 6.32%

What are the existing conditions these people have? *

  1. High Blood Pressure: 17 people, 17.89%
  2. High Blood Cholesterol: 11 people, 11.58%
  3. Stress And Anxiety: 7 people, 7.37%
  4. Depression: 7 people, 7.37%
  5. Dementia Alzheimer's Type (loss of mental ability with alzheimer's symptom): 7 people, 7.37%
  6. Hair Loss: 6 people, 6.32%
  7. Restless Leg Syndrome (a powerful urge to move your legs): 6 people, 6.32%
  8. Blood Testosterone Decreased: 5 people, 5.26%
  9. Migraine (headache): 4 people, 4.21%
  10. Mycosis Fungoides (lymphocytes (a type of white blood cell) become malignant (cancerous) and affect the skin): 4 people, 4.21%

* Approximation only. Some reports may have incomplete information.

Do you take Metformin and have Application site irritation?

- Check whether Application site irritation is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Metformin:

Application site irritation treatments and more:

How severe was Application site irritation and when was it recovered:

Expand to all the drugs that have ingredients of metformin hydrochloride:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Metformin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Application site irritation:

Browse all the conditions that are associated with Application site irritation:

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on metformin hydrochloride (the active ingredients of Metformin) and Metformin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

Recent studies on eHealthMe:

© 2026 eHealthMe.com. All rights reserved. Use of this site constitutes acceptance of eHealthMe.com's terms of service and privacy policy.