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Metformin and Application site scab - a phase IV clinical study of FDA data

Summary:

Application site scab is reported as a side effect among people who take Metformin (metformin hydrochloride), especially for people who are female, 60+ old, also take Lantus, and have Hair loss.

The phase IV clinical study analyzes which people have Application site scab when taking Metformin. It is created by eHealthMe based on reports of 453,860 people who have side effects when taking Metformin from the FDA, and is updated regularly.

What is Metformin?

Metformin has active ingredients of metformin hydrochloride. It is often used in diabetes. eHealthMe is studying from 465,358 Metformin users. Check the latest studies of Metformin.

What is Application site scab?

Application site scab (hard coating on the skin formed at application site) is found to be associated with 97 drugs and 283 conditions by eHealthMe. Check the latest studies of Application site scab.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

453,860 people reported to have side effects when taking Metformin.
Among them, 18 people (0.0%) have Application site scab.

Could Metformin cause Application site scab?

Among these 18 people:

What is the gender of people who have Application site scab when taking Metformin? *

  • female: 66.67 %
  • male: 33.33 %

What is the age of people who have Application site scab when taking Metformin? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 11.76 %
  • 50-59: 17.65 %
  • 60+: 70.59 %

What are other drugs people take besides Metformin? *

  1. Lantus: 6 people, 33.33%
  2. Valchlor: 5 people, 27.78%
  3. Regranex: 3 people, 16.67%
  4. Coq10: 3 people, 16.67%
  5. Turmeric: 3 people, 16.67%
  6. Novolog: 3 people, 16.67%
  7. Seroquel: 3 people, 16.67%
  8. Pramosone: 3 people, 16.67%
  9. Biotin: 2 people, 11.11%
  10. Vitamin B12: 2 people, 11.11%

What are other side effects people have besides Application site scab? *

  1. Application Site Pain: 11 people, 61.11%
  2. Application Site Pruritus (application site severe itching of the skin): 6 people, 33.33%
  3. Disease Progression: 4 people, 22.22%
  4. Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters): 4 people, 22.22%
  5. Application Site Dryness: 4 people, 22.22%
  6. Application Site Warmth: 4 people, 22.22%
  7. Skin Irritation: 4 people, 22.22%
  8. Application Site Rash: 4 people, 22.22%
  9. Skin Discoloration: 4 people, 22.22%
  10. Application Site Inflammation: 4 people, 22.22%

What are the existing conditions these people have? *

  1. Mycosis Fungoides (lymphocytes (a type of white blood cell) become malignant (cancerous) and affect the skin): 5 people, 27.78%
  2. Hair Loss: 5 people, 27.78%
  3. Essential Hypertension (primary hypertension): 4 people, 22.22%
  4. Thyroid Diseases: 3 people, 16.67%
  5. High Blood Cholesterol: 2 people, 11.11%
  6. Arthritis (form of joint disorder that involves inflammation of one or more joints): 2 people, 11.11%
  7. Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 1 person, 5.56%
  8. Basal Cell Carcinoma (a skin cancer, it rarely metastasizes or kills): 1 person, 5.56%
  9. Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 1 person, 5.56%
  10. Diabetic Ulcer: 1 person, 5.56%

* Approximation only. Some reports may have incomplete information.

Do you take Metformin and have Application site scab?

- Check whether Application site scab is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Metformin:

Application site scab treatments and more:

How severe was Application site scab and when was it recovered:

Expand to all the drugs that have ingredients of metformin hydrochloride:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Metformin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Application site scab:

Browse all the conditions that are associated with Application site scab:

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on metformin hydrochloride (the active ingredients of Metformin) and Metformin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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