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Metformin and Calculus bladder - a phase IV clinical study of FDA data

Summary:

Calculus bladder is reported as a side effect among people who take Metformin (metformin hydrochloride), especially for people who are male, 60+ old, have been taking the drug for 10+ years also take Actemra, and have Polychondritis.

The phase IV clinical study analyzes which people have Calculus bladder when taking Metformin. It is created by eHealthMe based on reports of 453,860 people who have side effects when taking Metformin from the FDA, and is updated regularly.

What is Metformin?

Metformin has active ingredients of metformin hydrochloride. It is often used in diabetes. eHealthMe is studying from 465,278 Metformin users. Check the latest studies of Metformin.

What is Calculus bladder?

Calculus bladder (bladder stone) is found to be associated with 251 drugs and 600 conditions by eHealthMe. Check the latest studies of Calculus bladder.

On Aug, 12, 2025

453,860 people reported to have side effects when taking Metformin.
Among them, 105 people (0.02%) have Calculus bladder.

Could Metformin cause Calculus bladder?

Among these 105 people:

How long have people been on Metformin when they have Calculus bladder? *

  • < 1 month: 0.0 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 100 %

What is the gender of people who have Calculus bladder when taking Metformin? *

  • female: 28.12 %
  • male: 71.88 %

What is the age of people who have Calculus bladder when taking Metformin? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 8.43 %
  • 50-59: 19.28 %
  • 60+: 72.29 %

What are other drugs people take besides Metformin? *

  1. Actemra: 27 people, 25.71%
  2. Januvia: 22 people, 20.95%
  3. Acetaminophen: 19 people, 18.10%
  4. Oxycodone: 19 people, 18.10%
  5. Valtrex: 18 people, 17.14%
  6. Diphenhydramine Hydrochloride: 16 people, 15.24%
  7. Pantoprazole Sodium: 16 people, 15.24%
  8. Risedronate Sodium: 16 people, 15.24%
  9. Methylprednisolone: 16 people, 15.24%
  10. Prednisone: 16 people, 15.24%

What are other side effects people have besides Calculus bladder? *

  1. Abdominal Pain: 49 people, 46.67%
  2. Pneumonia: 44 people, 41.90%
  3. Nasopharyngitis (inflammation of the nasopharynx): 44 people, 41.90%
  4. Peripheral Swelling: 44 people, 41.90%
  5. Cellulitis (infection under the skin): 42 people, 40.00%
  6. Drug Hypersensitivity: 37 people, 35.24%
  7. Pain: 37 people, 35.24%
  8. Dyspnea (difficult or laboured breathing): 36 people, 34.29%
  9. Weight Increased: 35 people, 33.33%
  10. Weakness: 33 people, 31.43%

What are the existing conditions these people have? *

  1. Polychondritis (progressive inflammation of cartilage and other connective tissue): 26 people, 24.76%
  2. Urinary Tract Infection: 16 people, 15.24%
  3. High Blood Pressure: 15 people, 14.29%
  4. Vasculitis Necrotising (inflammation and damage to blood vessels): 10 people, 9.52%
  5. Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 10 people, 9.52%
  6. Prostate Cancer: 8 people, 7.62%
  7. Chronic Myeloid Leukaemia (long lasting type of cancer that starts in the blood-forming cells of the bone marrow and invades the blood): 7 people, 6.67%
  8. Myelodysplastic Syndrome (a group of conditions that occur when the blood-forming cells in the bone marrow are damaged): 7 people, 6.67%
  9. Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 6 people, 5.71%
  10. Acromegaly (body produces too much growth hormone, leading to excess growth of body tissues): 5 people, 4.76%

* Approximation only. Some reports may have incomplete information.

Do you take Metformin and have Calculus bladder?

- Check whether Calculus bladder is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Metformin:

Calculus bladder treatments and more:

How severe was Calculus bladder and when was it recovered:

Expand to all the drugs that have ingredients of metformin hydrochloride:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Common Metformin side effects:

Browse all side effects of Metformin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Common drugs associated with Calculus bladder:

Browse all the drugs that are associated with Calculus bladder:

Common conditions associated with Calculus bladder:

Browse all the conditions that are associated with Calculus bladder:

Drugs similar to Metformin and Calculus bladder :

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on metformin hydrochloride (the active ingredients of Metformin) and Metformin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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