Metformin and Clonus - a phase IV clinical study of FDA data

Summary:

Clonus is reported as a side effect among people who take Metformin (metformin hydrochloride), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Amlodipine, and have Depression.

The phase IV clinical study analyzes which people have Clonus when taking Metformin. It is created by eHealthMe based on reports of 453,860 people who have side effects when taking Metformin from the FDA, and is updated regularly.

What is Metformin?

Metformin has active ingredients of metformin hydrochloride. It is often used in diabetes. eHealthMe is studying from 465,354 Metformin users. Check the latest studies of Metformin.

What is Clonus?

Clonus (series of involuntary, rhythmic, muscular contractions and relaxations) is found to be associated with 300 drugs and 560 conditions by eHealthMe. Check the latest studies of Clonus.

On Jul, 08, 2026

453,860 people reported to have side effects when taking Metformin.
Among them, 47 people (0.01%) have Clonus.

Among these 47 people:

How long have people been on Metformin when they have Clonus? *

What is the gender of people who have Clonus when taking Metformin? *

female: 52.27 %
male: 47.73 %

What is the age of people who have Clonus when taking Metformin? *

What are other drugs people take besides Metformin? *

What are other side effects people have besides Clonus? *

Serotonin Syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time): 22 people, 46.81%
Fall: 14 people, 29.79%
Hypertonia (abnormal increase in muscle tension and a reduced ability of a muscle to stretch): 12 people, 25.53%
Muscle Twitching: 11 people, 23.40%
Nausea And Vomiting: 9 people, 19.15%
Hyperreflexia (overactive or over responsive reflexes): 9 people, 19.15%
Coma Scale Abnormal: 9 people, 19.15%
Weight Decreased: 9 people, 19.15%
Myoclonus (a brief, involuntary twitching of a muscle or a group of muscles): 9 people, 19.15%
Weakness: 8 people, 17.02%

What are the existing conditions these people have? *

Depression: 10 people, 21.28%
Enterococcal Infection: 8 people, 17.02%
Pain: 5 people, 10.64%
Stress And Anxiety: 5 people, 10.64%
High Blood Pressure: 4 people, 8.51%
Insomnia (sleeplessness): 4 people, 8.51%
Procedural Pain: 4 people, 8.51%
Nausea (feeling of having an urge to vomit): 4 people, 8.51%
Affective Disorder (mental disorder): 3 people, 6.38%
Nervous System Disorder (a general class of medical conditions affecting the nervous system): 3 people, 6.38%

* Approximation only. Some reports may have incomplete information.

Do you take Metformin and have Clonus?

- Check whether Clonus is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Metformin:

Metformin (465,354 reports)

Clonus treatments and more:

Clonus (3,236 reports)

Browse all side effects of Metformin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Clonus:

Clonus (300 drugs)

Browse all the conditions that are associated with Clonus:

Clonus (560 conditions)

Related publications that referenced our studies

T.Audi Yanto, I.Huang, F.Nathania Kosasih, NP Hardjo Lugito, "Nightmare and Abnormal Dreams: Rare Side Effects of Metformin?", Case Reports in Endocrinology, 2018 Jan .
Al-Hamdy RA, "Assessment of electrolytes and HbA1c in type 2 diabetic patients using metformin and evaluation of guidelines obedience regarding renal impairment", J.Thi-Qar Sci., 2015 Jan .
Wiwanitkit S, Wiwanitkit V, "Metformin and sleep disorders", Indian journal of endocrinology and metabolism, 2012 Jan .
T.Audi Yanto, I.Huang, F.Nathania Kosasih, NP Hardjo Lugito, "Nightmare and Abnormal Dreams: Rare Side Effects of Metformin?", Case Reports in Endocrinology, 2018 Jan .
Al-Hamdy RA, "Assessment of electrolytes and HbA1c in type 2 diabetic patients using metformin and evaluation of guidelines obedience regarding renal impairment", J.Thi-Qar Sci., 2015 Jan .
Wiwanitkit S, Wiwanitkit V, "Metformin and sleep disorders", Indian journal of endocrinology and metabolism, 2012 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on metformin hydrochloride (the active ingredients of Metformin) and Metformin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.