Metformin and Constipation - a phase IV clinical study of FDA data

Summary:

Constipation is found among people who take Metformin, especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months.

The phase IV clinical study analyzes which people take Metformin and have Constipation. It is created by eHealthMe based on reports of 395,495 people who have side effects when taking Metformin from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Apr, 03, 2023

395,495 people reported to have side effects when taking Metformin.
Among them, 6,511 people (1.65%) have Constipation.

What is Metformin?

Metformin has active ingredients of metformin hydrochloride. It is often used in diabetes. eHealthMe is studying from 406,224 Metformin users for its effectiveness, alternative drugs and more.

What is Constipation?

Constipation is found to be associated with 4,470 drugs and 4,355 conditions by eHealthMe.

Number of Metformin and Constipation reports submitted per year:

* Approximation only. Some reports may have incomplete information.

Do you take Metformin and have Constipation?

Check whether Constipation is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related publications that referenced our studies

T.Audi Yanto, I.Huang, F.Nathania Kosasih, NP Hardjo Lugito, "Nightmare and Abnormal Dreams: Rare Side Effects of Metformin?", Case Reports in Endocrinology, 2018 Jan .
Al-Hamdy RA, "Assessment of electrolytes and HbA1c in type 2 diabetic patients using metformin and evaluation of guidelines obedience regarding renal impairment", J.Thi-Qar Sci., 2015 Jan .
Wiwanitkit S, Wiwanitkit V, "Metformin and sleep disorders", Indian journal of endocrinology and metabolism, 2012 Jan .

Related studies

How severe was Constipation and when was it recovered:

Constipation in Metformin

Expand to all the drugs that have ingredients of metformin hydrochloride:

Constipation and drugs with ingredients of metformin hydrochloride (6,391 reports)

Alternative drugs to, pros and cons of Metformin:

Metformin (406,224 reports)

Common Metformin side effects:

Diarrhea: 25,489 reports
Fatigue (feeling of tiredness): 22,049 reports
Drug ineffective: 20,041 reports
Nausea and vomiting: 17,857 reports
Weight decreased: 17,682 reports
Breathing difficulty: 16,617 reports

Browse all side effects of Metformin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Constipation treatments and more:

Constipation (290,406 reports)

COVID vaccines that are related to Constipation:

Common drugs associated with Constipation:

All the drugs that are associated with Constipation:

Constipation (4,470 drugs)

Common conditions associated with Constipation:

All the conditions that are associated with Constipation:

Constipation (4,355 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on metformin hydrochloride (the active ingredients of Metformin) and Metformin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.