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Metformin and Haemoglobinuria - a phase IV clinical study of FDA data

Summary:

Haemoglobinuria is reported as a side effect among people who take Metformin (metformin hydrochloride), especially for people who are male, 60+ old, also take Tapazole, and have High blood pressure.

The phase IV clinical study analyzes which people have Haemoglobinuria when taking Metformin. It is created by eHealthMe based on reports of 453,860 people who have side effects when taking Metformin from the FDA, and is updated regularly.

What is Metformin?

Metformin has active ingredients of metformin hydrochloride. It is often used in diabetes. eHealthMe is studying from 465,355 Metformin users. Check the latest studies of Metformin.

What is Haemoglobinuria?

Haemoglobinuria (the presence of free haemoglobin in the urine) is found to be associated with 84 drugs and 250 conditions by eHealthMe. Check the latest studies of Haemoglobinuria.

On Aug, 11, 2026

453,860 people reported to have side effects when taking Metformin.
Among them, 21 people (0.0%) have Haemoglobinuria.

Could Metformin cause Haemoglobinuria?

Among these 21 people:

What is the gender of people who have Haemoglobinuria when taking Metformin? *

  • female: 14.29 %
  • male: 85.71 %

What is the age of people who have Haemoglobinuria when taking Metformin? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 4.76 %
  • 30-39: 0.0 %
  • 40-49: 9.52 %
  • 50-59: 4.76 %
  • 60+: 80.95 %

What are other drugs people take besides Metformin? *

  1. Acetylsalicylic Acid: 9 people, 42.86%
  2. Tapazole: 9 people, 42.86%
  3. Soliris: 7 people, 33.33%
  4. Lorazepam: 3 people, 14.29%
  5. Voltaren: 2 people, 9.52%
  6. Norvasc: 2 people, 9.52%
  7. Actonel: 2 people, 9.52%
  8. Allopurinol: 2 people, 9.52%
  9. Avapro: 2 people, 9.52%
  10. Flomax: 2 people, 9.52%

What are other side effects people have besides Haemoglobinuria? *

  1. Nausea And Vomiting: 12 people, 57.14%
  2. Haematuria (presence of blood in urine): 11 people, 52.38%
  3. Lactic Acidosis (low ph in body tissues): 9 people, 42.86%
  4. Glycosuria (excretion of glucose into the urine): 9 people, 42.86%
  5. Urine Leukocyte Esterase Positive: 9 people, 42.86%
  6. Hyperglycemia (high blood sugar): 9 people, 42.86%
  7. Fever: 9 people, 42.86%
  8. Urine Ketone Body Present: 9 people, 42.86%
  9. Haemoglobin Decreased: 6 people, 28.57%
  10. Back Pain: 4 people, 19.05%

What are the existing conditions these people have? *

  1. High Blood Pressure: 13 people, 61.90%
  2. Hyperthyroidism (over activity of the thyroid gland): 9 people, 42.86%
  3. Myocardial Ischaemia (the blood flow through one or more of the blood vessels that lead to heart (coronary arteries) is decreased): 9 people, 42.86%
  4. Dementia Alzheimer's Type (loss of mental ability with alzheimer's symptom): 9 people, 42.86%
  5. Paroxysmal Nocturnal Haemoglobinuria (haemoglobin in the urine): 7 people, 33.33%
  6. Idiopathic Thrombocytopenic Purpura (bleeding disorder in which the immune system destroys platelets, which are necessary for normal blood clotting): 2 people, 9.52%
  7. Anaemia (lack of blood): 2 people, 9.52%
  8. Pain: 2 people, 9.52%
  9. Osteoporosis (bones weak and more likely to break): 1 person, 4.76%
  10. Glaucoma (increased fluid pressure in the eye with vision loss): 1 person, 4.76%

* Approximation only. Some reports may have incomplete information.

Do you take Metformin and have Haemoglobinuria?

- Check whether Haemoglobinuria is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Metformin:

Haemoglobinuria treatments and more:

How severe was Haemoglobinuria and when was it recovered:

Expand to all the drugs that have ingredients of metformin hydrochloride:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Metformin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Haemoglobinuria:

Browse all the conditions that are associated with Haemoglobinuria:

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on metformin hydrochloride (the active ingredients of Metformin) and Metformin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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