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Metformin and Interleukin level increased - a phase IV clinical study of FDA data

Summary:

Interleukin level increased is reported as a side effect among people who take Metformin (metformin hydrochloride), especially for people who are female, 40-49 old, have been taking the drug for < 1 month also take Ocrevus, and have High blood cholesterol.

The phase IV clinical study analyzes which people have Interleukin level increased when taking Metformin. It is created by eHealthMe based on reports of 453,860 people who have side effects when taking Metformin from the FDA, and is updated regularly.

What is Metformin?

Metformin has active ingredients of metformin hydrochloride. It is often used in diabetes. eHealthMe is studying from 465,355 Metformin users. Check the latest studies of Metformin.

What is Interleukin level increased?

Interleukin level increased is found to be associated with 66 drugs and 96 conditions by eHealthMe. Check the latest studies of Interleukin level increased.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 14, 2026

453,860 people reported to have side effects when taking Metformin.
Among them, 52 people (0.01%) have Interleukin level increased.

Could Metformin cause Interleukin level increased?

Among these 52 people:

How long have people been on Metformin when they have Interleukin level increased? *

  • < 1 month: 100 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

What is the gender of people who have Interleukin level increased when taking Metformin? *

  • female: 90.38 %
  • male: 9.62 %

What is the age of people who have Interleukin level increased when taking Metformin? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 3.85 %
  • 40-49: 86.54 %
  • 50-59: 5.77 %
  • 60+: 3.85 %

What are other drugs people take besides Metformin? *

  1. Ocrevus: 34 people, 65.38%
  2. Levetiracetam: 31 people, 59.62%
  3. Albuterol: 31 people, 59.62%
  4. Ibuprofen: 31 people, 59.62%
  5. Sodium Chloride: 31 people, 59.62%
  6. Simvastatin: 31 people, 59.62%
  7. Clemastine Fumarate: 23 people, 44.23%
  8. Doxycycline: 21 people, 40.38%
  9. Pantoprazole: 18 people, 34.62%
  10. Pantoprazole Sodium: 16 people, 30.77%

What are other side effects people have besides Interleukin level increased? *

  1. Diarrhea: 49 people, 94.23%
  2. Headache (pain in head): 47 people, 90.38%
  3. B-Lymphocyte Count Decreased: 45 people, 86.54%
  4. Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect): 45 people, 86.54%
  5. Nasopharyngitis (inflammation of the nasopharynx): 45 people, 86.54%
  6. Muscle Aches (muscle pain): 45 people, 86.54%
  7. Blood Glucose Increased: 45 people, 86.54%
  8. Joint Pain: 45 people, 86.54%
  9. Intervertebral Disc Protrusion (spinal disc protrusion): 45 people, 86.54%
  10. Nosebleed (bleeding from nose): 45 people, 86.54%

What are the existing conditions these people have? *

  1. Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 45 people, 86.54%
  2. Asthma: 45 people, 86.54%
  3. Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 45 people, 86.54%
  4. Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 45 people, 86.54%
  5. High Blood Cholesterol: 45 people, 86.54%
  6. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 23 people, 44.23%
  7. Pain: 3 people, 5.77%
  8. Sleep Disorder: 2 people, 3.85%
  9. Back Pain: 2 people, 3.85%
  10. Blood Glucose Increased: 2 people, 3.85%

* Approximation only. Some reports may have incomplete information.

Do you take Metformin and have Interleukin level increased?

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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Metformin:

Interleukin level increased treatments and more:

How severe was Interleukin level increased and when was it recovered:

Expand to all the drugs that have ingredients of metformin hydrochloride:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Metformin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Interleukin level increased:

Browse all the conditions that are associated with Interleukin level increased:

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on metformin hydrochloride (the active ingredients of Metformin) and Metformin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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