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Metformin and Joint warmth - a phase IV clinical study of FDA data

Summary:

Joint warmth is reported as a side effect among people who take Metformin (metformin hydrochloride), especially for people who are male, 60+ old, also take Lyrica, and have Rheumatoid arthritis.

The phase IV clinical study analyzes which people have Joint warmth when taking Metformin. It is created by eHealthMe based on reports of 453,860 people who have side effects when taking Metformin from the FDA, and is updated regularly.

What is Metformin?

Metformin has active ingredients of metformin hydrochloride. It is often used in diabetes. eHealthMe is studying from 465,355 Metformin users. Check the latest studies of Metformin.

What is Joint warmth?

Joint warmth is found to be associated with 165 drugs and 250 conditions by eHealthMe. Check the latest studies of Joint warmth.

On Aug, 02, 2026

453,860 people reported to have side effects when taking Metformin.
Among them, 40 people (0.01%) have Joint warmth.

Could Metformin cause Joint warmth?

Among these 40 people:

What is the gender of people who have Joint warmth when taking Metformin? *

  • female: 50 %
  • male: 50 %

What is the age of people who have Joint warmth when taking Metformin? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 2.78 %
  • 40-49: 19.44 %
  • 50-59: 16.67 %
  • 60+: 61.11 %

What are other drugs people take besides Metformin? *

  1. Lyrica: 11 people, 27.50%
  2. Humira: 10 people, 25.00%
  3. Benadryl: 8 people, 20.00%
  4. Gabapentin: 6 people, 15.00%
  5. Prilosec: 6 people, 15.00%
  6. Oxycodone And Acetaminophen: 6 people, 15.00%
  7. Levaquin: 6 people, 15.00%
  8. Advair Hfa: 5 people, 12.50%
  9. Vitamin B12: 5 people, 12.50%
  10. Lisinopril: 4 people, 10.00%

What are other side effects people have besides Joint warmth? *

  1. Joint Swelling: 24 people, 60.00%
  2. Joint Pain: 24 people, 60.00%
  3. Rashes (redness): 18 people, 45.00%
  4. Fatigue (feeling of tiredness): 14 people, 35.00%
  5. Diarrhea: 11 people, 27.50%
  6. Cough: 11 people, 27.50%
  7. Malaise (a feeling of general discomfort or uneasiness): 10 people, 25.00%
  8. Pain: 10 people, 25.00%
  9. Osteomyelitis Chronic (long lasting infection of bone marrow): 9 people, 22.50%
  10. Pain In Extremity: 9 people, 22.50%

What are the existing conditions these people have? *

  1. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 13 people, 32.50%
  2. Pain: 8 people, 20.00%
  3. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 15.00%
  4. Pain In Extremity: 6 people, 15.00%
  5. Neuropathy Peripheral (surface nerve damage): 6 people, 15.00%
  6. Diabetic Neuropathy (neuropathic disorders that are associated with diabetes mellitus): 6 people, 15.00%
  7. Hypomagnesaemia (electrolyte disturbance in which there is an abnormally low level of magnesium in the blood): 6 people, 15.00%
  8. Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 5 people, 12.50%
  9. Neck Pain: 5 people, 12.50%
  10. Pulmonary Hypertension (increase in blood pressure in the lung artery): 3 people, 7.50%

* Approximation only. Some reports may have incomplete information.

Do you take Metformin and have Joint warmth?

- Check whether Joint warmth is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Metformin:

Joint warmth treatments and more:

How severe was Joint warmth and when was it recovered:

Expand to all the drugs that have ingredients of metformin hydrochloride:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Metformin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Joint warmth:

Browse all the conditions that are associated with Joint warmth:

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on metformin hydrochloride (the active ingredients of Metformin) and Metformin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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