Metformin and Lichenification - a phase IV clinical study of FDA data

Summary:

Lichenification is reported as a side effect among people who take Metformin (metformin hydrochloride), especially for people who are male, 60+ old, also take Eliquis, and have High blood cholesterol.

The phase IV clinical study analyzes which people have Lichenification when taking Metformin. It is created by eHealthMe based on reports of 453,860 people who have side effects when taking Metformin from the FDA, and is updated regularly.

What is Metformin?

Metformin has active ingredients of metformin hydrochloride. It is often used in diabetes. eHealthMe is studying from 465,354 Metformin users. Check the latest studies of Metformin.

What is Lichenification?

Lichenification (thickening and hardening of the skin) is found to be associated with 94 drugs and 167 conditions by eHealthMe. Check the latest studies of Lichenification.

On Jul, 15, 2026

453,860 people reported to have side effects when taking Metformin.
Among them, 32 people (0.01%) have Lichenification.

Among these 32 people:

What is the gender of people who have Lichenification when taking Metformin? *

female: 37.93 %
male: 62.07 %

What is the age of people who have Lichenification when taking Metformin? *

What are other drugs people take besides Metformin? *

What are other side effects people have besides Lichenification? *

Dermatitis Exfoliative Generalised (inflammatory skin disease with erythema and scaling that affects nearly the entire cutaneous surface): 17 people, 53.12%
Drug Hypersensitivity: 9 people, 28.12%
Rashes (redness): 9 people, 28.12%
Psoriasis (immune-mediated disease that affects the skin): 5 people, 15.62%
Rash Erythematous (redness of the skin): 4 people, 12.50%
Itching: 4 people, 12.50%
Joint Pain: 4 people, 12.50%
Intertrigo (inflammation (rash) of the body folds (adjacent areas of skin)): 4 people, 12.50%
Seborrhoeic Keratosis (noncancerous (benign) skin growths that some people develop as they age. they often appear on the back or chest): 4 people, 12.50%
Skin Irritation: 4 people, 12.50%

What are the existing conditions these people have? *

High Blood Cholesterol: 6 people, 18.75%
Psoriasis (immune-mediated disease that affects the skin): 3 people, 9.38%
Stress And Anxiety: 1 person, 3.12%
Intertrigo (inflammation (rash) of the body folds (adjacent areas of skin)): 1 person, 3.12%
Depression: 1 person, 3.12%
Back Pain: 1 person, 3.12%

* Approximation only. Some reports may have incomplete information.

Do you take Metformin and have Lichenification?

- Check whether Lichenification is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Metformin:

Metformin (465,354 reports)

Browse all side effects of Metformin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Lichenification:

Lichenification (94 drugs)

Browse all the conditions that are associated with Lichenification:

Lichenification (167 conditions)

Related publications that referenced our studies

T.Audi Yanto, I.Huang, F.Nathania Kosasih, NP Hardjo Lugito, "Nightmare and Abnormal Dreams: Rare Side Effects of Metformin?", Case Reports in Endocrinology, 2018 Jan .
Al-Hamdy RA, "Assessment of electrolytes and HbA1c in type 2 diabetic patients using metformin and evaluation of guidelines obedience regarding renal impairment", J.Thi-Qar Sci., 2015 Jan .
Wiwanitkit S, Wiwanitkit V, "Metformin and sleep disorders", Indian journal of endocrinology and metabolism, 2012 Jan .
T.Audi Yanto, I.Huang, F.Nathania Kosasih, NP Hardjo Lugito, "Nightmare and Abnormal Dreams: Rare Side Effects of Metformin?", Case Reports in Endocrinology, 2018 Jan .
Al-Hamdy RA, "Assessment of electrolytes and HbA1c in type 2 diabetic patients using metformin and evaluation of guidelines obedience regarding renal impairment", J.Thi-Qar Sci., 2015 Jan .
Wiwanitkit S, Wiwanitkit V, "Metformin and sleep disorders", Indian journal of endocrinology and metabolism, 2012 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on metformin hydrochloride (the active ingredients of Metformin) and Metformin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.