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Metformin and Muscle contracture - a phase IV clinical study of FDA data

Summary:

Muscle contracture is reported as a side effect among people who take Metformin (metformin hydrochloride), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Lyrica, and have High blood pressure.

The phase IV clinical study analyzes which people have Muscle contracture when taking Metformin. It is created by eHealthMe based on reports of 453,860 people who have side effects when taking Metformin from the FDA, and is updated regularly.

What is Metformin?

Metformin has active ingredients of metformin hydrochloride. It is often used in diabetes. eHealthMe is studying from 465,355 Metformin users. Check the latest studies of Metformin.

What is Muscle contracture?

Muscle contracture (a permanent shortening of a muscle) is found to be associated with 329 drugs and 525 conditions by eHealthMe. Check the latest studies of Muscle contracture.

On Aug, 05, 2026

453,860 people reported to have side effects when taking Metformin.
Among them, 52 people (0.01%) have Muscle contracture.

Could Metformin cause Muscle contracture?

Among these 52 people:

How long have people been on Metformin when they have Muscle contracture? *

  • < 1 month: 100 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

What is the gender of people who have Muscle contracture when taking Metformin? *

  • female: 59.57 %
  • male: 40.43 %

What is the age of people who have Muscle contracture when taking Metformin? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 5.41 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 21.62 %
  • 50-59: 35.14 %
  • 60+: 37.84 %

What are other drugs people take besides Metformin? *

  1. Lyrica: 11 people, 21.15%
  2. Amlodipine: 5 people, 9.62%
  3. Neurontin: 4 people, 7.69%
  4. Vitamin D3: 4 people, 7.69%
  5. Vitamin D: 4 people, 7.69%
  6. Pregabalin: 3 people, 5.77%
  7. Cosentyx: 3 people, 5.77%
  8. Kisqali: 3 people, 5.77%
  9. Vitamin B6: 3 people, 5.77%
  10. Vitamin B12: 3 people, 5.77%

What are other side effects people have besides Muscle contracture? *

  1. Nausea (feeling of having an urge to vomit): 15 people, 28.85%
  2. Nausea And Vomiting: 13 people, 25.00%
  3. Gait Disturbance: 11 people, 21.15%
  4. Hypoaesthesia (reduced sense of touch or sensation): 11 people, 21.15%
  5. Pain In Extremity: 11 people, 21.15%
  6. Dizziness: 10 people, 19.23%
  7. Memory Loss: 10 people, 19.23%
  8. Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect): 9 people, 17.31%
  9. Pain: 8 people, 15.38%
  10. Pneumonia: 7 people, 13.46%

What are the existing conditions these people have? *

  1. High Blood Cholesterol: 6 people, 11.54%
  2. High Blood Pressure: 6 people, 11.54%
  3. Diarrhea: 4 people, 7.69%
  4. Constipation: 4 people, 7.69%
  5. Breakthrough Pain: 3 people, 5.77%
  6. Dyspnea (difficult or laboured breathing): 3 people, 5.77%
  7. Vitamin D Decreased: 3 people, 5.77%
  8. Neuropathy Peripheral (surface nerve damage): 3 people, 5.77%
  9. Osteoarthritis (a joint disease caused by cartilage loss in a joint): 3 people, 5.77%
  10. Breast Cancer: 3 people, 5.77%

* Approximation only. Some reports may have incomplete information.

Do you take Metformin and have Muscle contracture?

- Check whether Muscle contracture is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Metformin:

Muscle contracture treatments and more:

How severe was Muscle contracture and when was it recovered:

Expand to all the drugs that have ingredients of metformin hydrochloride:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Metformin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Muscle contracture:

Browse all the conditions that are associated with Muscle contracture:

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on metformin hydrochloride (the active ingredients of Metformin) and Metformin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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