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Metformin and Persistent left superior vena cava - a phase IV clinical study of FDA data

Summary:

Persistent left superior vena cava is reported as a side effect among people who take Metformin (metformin hydrochloride), especially for people who are female, 0-1 old, also take Venlafaxine Hydrochloride, and have Depression.

The phase IV clinical study analyzes which people have Persistent left superior vena cava when taking Metformin. It is created by eHealthMe based on reports of 453,860 people who have side effects when taking Metformin from the FDA, and is updated regularly.

What is Metformin?

Metformin has active ingredients of metformin hydrochloride. It is often used in diabetes. eHealthMe is studying from 465,355 Metformin users. Check the latest studies of Metformin.

What is Persistent left superior vena cava?

Persistent left superior vena cava (variation of the thoracic venous system) is found to be associated with 7 drugs and 39 conditions by eHealthMe. Check the latest studies of Persistent left superior vena cava.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 17, 2026

453,860 people reported to have side effects when taking Metformin.
Among them, 14 people (0.0%) have Persistent left superior vena cava.

Could Metformin cause Persistent left superior vena cava?

Among these 14 people:

What is the gender of people who have Persistent left superior vena cava when taking Metformin? *

  • female: 100 %
  • male: 0.0 %

What is the age of people who have Persistent left superior vena cava when taking Metformin? *

  • 0-1: 100 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 0.0 %
  • 50-59: 0.0 %
  • 60+: 0.0 %

What are other drugs people take besides Metformin? *

  1. Venlafaxine Hydrochloride: 3 people, 21.43%
  2. Fragmin: 2 people, 14.29%
  3. Clotrimazole: 1 person, 7.14%

What are other side effects people have besides Persistent left superior vena cava? *

  1. Right Aortic Arch: 14 people, 100.00%
  2. Imperforate Anus (congenital defect of the anus; there is partial or complete obstruction of the anal opening): 14 people, 100.00%
  3. Premature Baby: 6 people, 42.86%
  4. Foetal Exposure During Pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect): 4 people, 28.57%
  5. Maternal Exposure During Pregnancy (use of substance during pregnancy): 2 people, 14.29%

What are the existing conditions these people have? *

  1. Depression: 7 people, 50.00%
  2. Vulvovaginal Mycotic Infection (vulvovaginal fungal infection): 5 people, 35.71%

* Approximation only. Some reports may have incomplete information.

Do you take Metformin and have Persistent left superior vena cava?

- Check whether Persistent left superior vena cava is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Metformin:

Persistent left superior vena cava treatments and more:

How severe was Persistent left superior vena cava and when was it recovered:

Expand to all the drugs that have ingredients of metformin hydrochloride:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Metformin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Persistent left superior vena cava:

Browse all the conditions that are associated with Persistent left superior vena cava:

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on metformin hydrochloride (the active ingredients of Metformin) and Metformin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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