Metformin and Synovial rupture - a phase IV clinical study of FDA data

Summary:

Synovial rupture is reported as a side effect among people who take Metformin (metformin hydrochloride), especially for people who are female, 60+ old, also take Centrum, and have Rheumatoid arthritis.

The phase IV clinical study analyzes which people have Synovial rupture when taking Metformin. It is created by eHealthMe based on reports of 453,860 people who have side effects when taking Metformin from the FDA, and is updated regularly.

What is Metformin?

Metformin has active ingredients of metformin hydrochloride. It is often used in diabetes. eHealthMe is studying from 465,355 Metformin users. Check the latest studies of Metformin.

What is Synovial rupture?

Synovial rupture (tear of synovial membrane of joint) is found to be associated with 118 drugs and 158 conditions by eHealthMe. Check the latest studies of Synovial rupture.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 27, 2026

453,860 people reported to have side effects when taking Metformin.
Among them, 11 people (0.0%) have Synovial rupture.

Among these 11 people:

What is the gender of people who have Synovial rupture when taking Metformin? *

female: 72.73 %
male: 27.27 %

What is the age of people who have Synovial rupture when taking Metformin? *

What are other drugs people take besides Metformin? *

What are other side effects people have besides Synovial rupture? *

High Blood Pressure: 6 people, 54.55%
Fatigue (feeling of tiredness): 5 people, 45.45%
Muscle Spasms (muscle contraction): 4 people, 36.36%
Muscle Injury: 4 people, 36.36%
Inflammation: 4 people, 36.36%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 4 people, 36.36%
Musculoskeletal Stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves): 4 people, 36.36%
Speech Impairment (Adult) (inability to speak (adult)): 4 people, 36.36%
Migraine (headache): 4 people, 36.36%
Discomfort: 4 people, 36.36%

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 6 people, 54.55%
Pain: 5 people, 45.45%
Muscle Spasms (muscle contraction): 4 people, 36.36%
Inflammation: 4 people, 36.36%
High Blood Cholesterol: 4 people, 36.36%
Cough: 2 people, 18.18%
Bronchospasm (spasm of bronchial smooth muscle producing narrowing of the bronchi): 2 people, 18.18%
Asthma: 2 people, 18.18%
Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 1 person, 9.09%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

Do you take Metformin and have Synovial rupture?

- Check whether Synovial rupture is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Metformin:

Metformin (465,355 reports)

Browse all side effects of Metformin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Synovial rupture:

Synovial rupture (118 drugs)

Browse all the conditions that are associated with Synovial rupture:

Synovial rupture (158 conditions)

Related publications that referenced our studies

T.Audi Yanto, I.Huang, F.Nathania Kosasih, NP Hardjo Lugito, "Nightmare and Abnormal Dreams: Rare Side Effects of Metformin?", Case Reports in Endocrinology, 2018 Jan .
Al-Hamdy RA, "Assessment of electrolytes and HbA1c in type 2 diabetic patients using metformin and evaluation of guidelines obedience regarding renal impairment", J.Thi-Qar Sci., 2015 Jan .
Wiwanitkit S, Wiwanitkit V, "Metformin and sleep disorders", Indian journal of endocrinology and metabolism, 2012 Jan .
T.Audi Yanto, I.Huang, F.Nathania Kosasih, NP Hardjo Lugito, "Nightmare and Abnormal Dreams: Rare Side Effects of Metformin?", Case Reports in Endocrinology, 2018 Jan .
Al-Hamdy RA, "Assessment of electrolytes and HbA1c in type 2 diabetic patients using metformin and evaluation of guidelines obedience regarding renal impairment", J.Thi-Qar Sci., 2015 Jan .
Wiwanitkit S, Wiwanitkit V, "Metformin and sleep disorders", Indian journal of endocrinology and metabolism, 2012 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on metformin hydrochloride (the active ingredients of Metformin) and Metformin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.