Metformin and Thyroid nodule - a phase IV clinical study of FDA data

Summary:

Thyroid nodule is reported as a side effect among people who take Metformin (metformin hydrochloride), especially for people who are male, 50-59 old, also take Levaquin, and have High blood pressure.

The phase IV clinical study analyzes which people have Thyroid nodule when taking Metformin. It is created by eHealthMe based on reports of 453,860 people who have side effects when taking Metformin from the FDA, and is updated regularly.

What is Metformin?

Metformin has active ingredients of metformin hydrochloride. It is often used in diabetes. eHealthMe is studying from 465,354 Metformin users. Check the latest studies of Metformin.

What is Thyroid nodule?

Thyroid nodule (a growth (lump) in the thyroid gland) is found to be associated with 112 drugs and 260 conditions by eHealthMe. Check the latest studies of Thyroid nodule.

On Jul, 15, 2026

453,860 people reported to have side effects when taking Metformin.
Among them, 25 people (0.01%) have Thyroid nodule.

Among these 25 people:

What is the gender of people who have Thyroid nodule when taking Metformin? *

female: 36 %
male: 64 %

What is the age of people who have Thyroid nodule when taking Metformin? *

What are other drugs people take besides Metformin? *

What are other side effects people have besides Thyroid nodule? *

White Blood Cell Count Decreased: 10 people, 40.00%
Infection: 10 people, 40.00%
Osteonecrosis Of Jaw (death of bone of jaw): 10 people, 40.00%
Osteomyelitis (infection of bone): 10 people, 40.00%
Oral Herpes (viral infection of mouth): 10 people, 40.00%
Mucosal Inflammation (infection of mucous membrane): 10 people, 40.00%
Mouth Ulcers: 10 people, 40.00%
Lichen Planus (an inflammatory skin condition, characterized by an itchy, non-infectious rash): 10 people, 40.00%
Leukoplakia Oral (white and gray patches inside the mouth): 10 people, 40.00%
Leukocytosis (increased white blood cells): 10 people, 40.00%

What are the existing conditions these people have? *

Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 3 people, 12.00%
High Blood Pressure: 3 people, 12.00%
Hyperlipidaemia (presence of excess lipids in the blood): 2 people, 8.00%
Heart Rate Irregular: 2 people, 8.00%
Cardiac Disorder: 2 people, 8.00%
Asthma: 2 people, 8.00%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 1 person, 4.00%
Pain: 1 person, 4.00%
Insomnia (sleeplessness): 1 person, 4.00%
Hypertonia (abnormal increase in muscle tension and a reduced ability of a muscle to stretch): 1 person, 4.00%

* Approximation only. Some reports may have incomplete information.

Do you take Metformin and have Thyroid nodule?

- Check whether Thyroid nodule is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Metformin:

Metformin (465,354 reports)

Browse all side effects of Metformin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Thyroid nodule:

Thyroid nodule (112 drugs)

Browse all the conditions that are associated with Thyroid nodule:

Thyroid nodule (260 conditions)

Related publications that referenced our studies

T.Audi Yanto, I.Huang, F.Nathania Kosasih, NP Hardjo Lugito, "Nightmare and Abnormal Dreams: Rare Side Effects of Metformin?", Case Reports in Endocrinology, 2018 Jan .
Al-Hamdy RA, "Assessment of electrolytes and HbA1c in type 2 diabetic patients using metformin and evaluation of guidelines obedience regarding renal impairment", J.Thi-Qar Sci., 2015 Jan .
Wiwanitkit S, Wiwanitkit V, "Metformin and sleep disorders", Indian journal of endocrinology and metabolism, 2012 Jan .
T.Audi Yanto, I.Huang, F.Nathania Kosasih, NP Hardjo Lugito, "Nightmare and Abnormal Dreams: Rare Side Effects of Metformin?", Case Reports in Endocrinology, 2018 Jan .
Al-Hamdy RA, "Assessment of electrolytes and HbA1c in type 2 diabetic patients using metformin and evaluation of guidelines obedience regarding renal impairment", J.Thi-Qar Sci., 2015 Jan .
Wiwanitkit S, Wiwanitkit V, "Metformin and sleep disorders", Indian journal of endocrinology and metabolism, 2012 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on metformin hydrochloride (the active ingredients of Metformin) and Metformin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.