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Metformin and Thyroxine increased - a phase IV clinical study of FDA data

Summary:

Thyroxine increased is reported as a side effect among people who take Metformin (metformin hydrochloride), especially for people who are female, 50-59 old, also take Sertraline, and have Atrial fibrillation/flutter.

The phase IV clinical study analyzes which people have Thyroxine increased when taking Metformin. It is created by eHealthMe based on reports of 453,860 people who have side effects when taking Metformin from the FDA, and is updated regularly.

What is Metformin?

Metformin has active ingredients of metformin hydrochloride. It is often used in diabetes. eHealthMe is studying from 465,355 Metformin users. Check the latest studies of Metformin.

What is Thyroxine increased?

Thyroxine increased is found to be associated with 94 drugs and 222 conditions by eHealthMe. Check the latest studies of Thyroxine increased.

On Aug, 01, 2026

453,860 people reported to have side effects when taking Metformin.
Among them, 18 people (0.0%) have Thyroxine increased.

Could Metformin cause Thyroxine increased?

Among these 18 people:

What is the gender of people who have Thyroxine increased when taking Metformin? *

  • female: 77.78 %
  • male: 22.22 %

What is the age of people who have Thyroxine increased when taking Metformin? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 0.0 %
  • 50-59: 56.25 %
  • 60+: 43.75 %

What are other drugs people take besides Metformin? *

  1. Sertraline: 6 people, 33.33%
  2. Levoxyl: 3 people, 16.67%
  3. Advair Diskus 100/50: 2 people, 11.11%
  4. Amaryl: 2 people, 11.11%
  5. Avandia: 2 people, 11.11%
  6. Cozaar: 2 people, 11.11%
  7. Valproic Acid: 2 people, 11.11%
  8. Oxybutynin: 2 people, 11.11%
  9. Warfarin Sodium: 2 people, 11.11%
  10. Acetaminophen: 2 people, 11.11%

What are other side effects people have besides Thyroxine increased? *

  1. Tri-Iodothyronine Increased: 8 people, 44.44%
  2. Dehydration (dryness resulting from the removal of water): 6 people, 33.33%
  3. Blood Thyroid Stimulating Hormone Decreased: 6 people, 33.33%
  4. Fever: 6 people, 33.33%
  5. Abdominal Pain Upper: 6 people, 33.33%
  6. Thyrotoxic Crisis (a life threatening condition due to excess secretion of thyroid hormone): 6 people, 33.33%
  7. Agitation (state of anxiety or nervous excitement): 6 people, 33.33%
  8. Thyroglobulin Increased: 6 people, 33.33%
  9. Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 6 people, 33.33%
  10. Psychomotor Hyperactivity (feelings of extreme restlessness): 6 people, 33.33%

What are the existing conditions these people have? *

  1. Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 6 people, 33.33%
  2. Thyroid Diseases: 2 people, 11.11%
  3. Osteoarthritis (a joint disease caused by cartilage loss in a joint): 2 people, 11.11%
  4. Joint Pain: 2 people, 11.11%
  5. Asthma: 2 people, 11.11%
  6. Squamous Cell Carcinoma Of Skin (a cancer of a kind of epithelial cell, the squamous cell. these cells are the main part of the epidermis of the skin): 1 person, 5.56%
  7. Pain In Extremity: 1 person, 5.56%
  8. Muscle Spasms (muscle contraction): 1 person, 5.56%
  9. Metastases To Lymph Nodes (cancer spreads to lymph node): 1 person, 5.56%
  10. Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 1 person, 5.56%

* Approximation only. Some reports may have incomplete information.

Do you take Metformin and have Thyroxine increased?

- Check whether Thyroxine increased is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Metformin:

Thyroxine increased treatments and more:

How severe was Thyroxine increased and when was it recovered:

Expand to all the drugs that have ingredients of metformin hydrochloride:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Metformin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Thyroxine increased:

Browse all the conditions that are associated with Thyroxine increased:

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on metformin hydrochloride (the active ingredients of Metformin) and Metformin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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