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Metformin and Tryptase increased - a phase IV clinical study of FDA data

Summary:

Tryptase increased is reported as a side effect among people who take Metformin (metformin hydrochloride), especially for people who are female, 50-59 old, also take Tylenol, and have Urticaria.

The phase IV clinical study analyzes which people have Tryptase increased when taking Metformin. It is created by eHealthMe based on reports of 453,860 people who have side effects when taking Metformin from the FDA, and is updated regularly.

What is Metformin?

Metformin has active ingredients of metformin hydrochloride. It is often used in diabetes. eHealthMe is studying from 465,354 Metformin users. Check the latest studies of Metformin.

What is Tryptase increased?

Tryptase increased is found to be associated with 72 drugs and 123 conditions by eHealthMe. Check the latest studies of Tryptase increased.

On Jul, 15, 2026

453,860 people reported to have side effects when taking Metformin.
Among them, 15 people (0.0%) have Tryptase increased.

Could Metformin cause Tryptase increased?

Among these 15 people:

What is the gender of people who have Tryptase increased when taking Metformin? *

  • female: 92.86 %
  • male: 7.14 %

What is the age of people who have Tryptase increased when taking Metformin? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 0.0 %
  • 50-59: 58.33 %
  • 60+: 41.67 %

What are other drugs people take besides Metformin? *

  1. Tylenol: 8 people, 53.33%
  2. Chlorthalidone: 7 people, 46.67%
  3. Prednisone: 7 people, 46.67%
  4. Januvia: 7 people, 46.67%
  5. Potassium Chloride: 7 people, 46.67%
  6. Epipen: 2 people, 13.33%
  7. Epinephrine: 2 people, 13.33%
  8. Pantoprazole: 2 people, 13.33%
  9. Zyrtec: 2 people, 13.33%
  10. Furosemide: 2 people, 13.33%

What are other side effects people have besides Tryptase increased? *

  1. Hypokalemia (low potassium): 7 people, 46.67%
  2. Urticaria (rash of round, red welts on the skin that itch intensely): 7 people, 46.67%
  3. Fever: 7 people, 46.67%
  4. Itching: 7 people, 46.67%
  5. Anaphylaxis (serious allergic reaction that is rapid in onset and may cause death): 4 people, 26.67%
  6. Hypotension (abnormally low blood pressure): 3 people, 20.00%
  7. Fall: 2 people, 13.33%
  8. Arrhythmias (irregular heartbeat): 2 people, 13.33%
  9. Pulseless Electrical Activity: 2 people, 13.33%
  10. Hepatic Pain (pain in liver): 2 people, 13.33%

What are the existing conditions these people have? *

  1. Urticaria (rash of round, red welts on the skin that itch intensely): 6 people, 40.00%
  2. High Blood Cholesterol: 2 people, 13.33%
  3. Hypotension (abnormally low blood pressure): 1 person, 6.67%
  4. Diarrhea: 1 person, 6.67%
  5. Gastric Disorder (disease of stomach): 1 person, 6.67%
  6. General Anaesthesia: 1 person, 6.67%
  7. Headache (pain in head): 1 person, 6.67%
  8. Hereditary Angioedema (recurrent episodes of severe swelling): 1 person, 6.67%
  9. High Blood Pressure: 1 person, 6.67%
  10. Hypotonia (low muscle tone): 1 person, 6.67%

* Approximation only. Some reports may have incomplete information.

Do you take Metformin and have Tryptase increased?

- Check whether Tryptase increased is associated with a drug or a condition
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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Metformin:

Tryptase increased treatments and more:

How severe was Tryptase increased and when was it recovered:

Expand to all the drugs that have ingredients of metformin hydrochloride:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Metformin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Tryptase increased:

Browse all the conditions that are associated with Tryptase increased:

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on metformin hydrochloride (the active ingredients of Metformin) and Metformin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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