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Metformin and Tympanic membrane disorder - a phase IV clinical study of FDA data

Summary:

Tympanic membrane disorder is reported as a side effect among people who take Metformin (metformin hydrochloride), especially for people who are male, 40-49 old, also take Glyburide, and have Suicide attempt.

The phase IV clinical study analyzes which people have Tympanic membrane disorder when taking Metformin. It is created by eHealthMe based on reports of 453,860 people who have side effects when taking Metformin from the FDA, and is updated regularly.

What is Metformin?

Metformin has active ingredients of metformin hydrochloride. It is often used in diabetes. eHealthMe is studying from 465,358 Metformin users. Check the latest studies of Metformin.

What is Tympanic membrane disorder?

Tympanic membrane disorder (disease of ear drum) is found to be associated with 140 drugs and 192 conditions by eHealthMe. Check the latest studies of Tympanic membrane disorder.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

453,860 people reported to have side effects when taking Metformin.
Among them, 14 people (0.0%) have Tympanic membrane disorder.

Could Metformin cause Tympanic membrane disorder?

Among these 14 people:

What is the gender of people who have Tympanic membrane disorder when taking Metformin? *

  • female: 41.67 %
  • male: 58.33 %

What is the age of people who have Tympanic membrane disorder when taking Metformin? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 9.09 %
  • 30-39: 0.0 %
  • 40-49: 63.64 %
  • 50-59: 18.18 %
  • 60+: 9.09 %

What are other drugs people take besides Metformin? *

  1. Glyburide: 6 people, 42.86%
  2. Gemfibrozil: 4 people, 28.57%
  3. Lisinopril: 4 people, 28.57%
  4. Xopenex: 3 people, 21.43%
  5. Vardenafil Hydrochloride: 3 people, 21.43%
  6. Tramadol: 3 people, 21.43%
  7. Synthroid: 3 people, 21.43%
  8. Prevacid: 3 people, 21.43%
  9. Flagyl: 2 people, 14.29%
  10. Duoneb: 2 people, 14.29%

What are other side effects people have besides Tympanic membrane disorder? *

  1. Hypotension (abnormally low blood pressure): 7 people, 50.00%
  2. Thrombocytopenia (decrease of platelets in blood): 7 people, 50.00%
  3. Deafness Neurosensory: 6 people, 42.86%
  4. Acute Kidney Failure: 6 people, 42.86%
  5. Lactic Acidosis (low ph in body tissues): 6 people, 42.86%
  6. Leukocytosis (increased white blood cells): 6 people, 42.86%
  7. Hypoglycemia (low blood sugar): 6 people, 42.86%
  8. Hypernatraemia (an abnormally high plasma concentration of sodium ions): 6 people, 42.86%
  9. Hyperglycemia (high blood sugar): 6 people, 42.86%
  10. Suicide Attempt: 6 people, 42.86%

What are the existing conditions these people have? *

  1. Suicide Attempt: 3 people, 21.43%
  2. Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 2 people, 14.29%
  3. Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 2 people, 14.29%
  4. Asthma: 2 people, 14.29%
  5. Vitamin B12 Deficiency: 1 person, 7.14%
  6. Stress And Anxiety: 1 person, 7.14%
  7. Spinal Disorder (disease of spine a back bone): 1 person, 7.14%
  8. Pain: 1 person, 7.14%
  9. Metastases To Bone (cancer spreads to bone): 1 person, 7.14%
  10. High Blood Pressure: 1 person, 7.14%

* Approximation only. Some reports may have incomplete information.

Do you take Metformin and have Tympanic membrane disorder?

- Check whether Tympanic membrane disorder is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Metformin:

Tympanic membrane disorder treatments and more:

How severe was Tympanic membrane disorder and when was it recovered:

Expand to all the drugs that have ingredients of metformin hydrochloride:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Metformin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Tympanic membrane disorder:

Browse all the conditions that are associated with Tympanic membrane disorder:

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on metformin hydrochloride (the active ingredients of Metformin) and Metformin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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