Metformin and Underweight - a phase IV clinical study of FDA data

Summary:

Underweight is reported as a side effect among people who take Metformin (metformin hydrochloride), especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months also take Lyrica, and have Asthma.

The phase IV clinical study analyzes which people have Underweight when taking Metformin. It is created by eHealthMe based on reports of 453,860 people who have side effects when taking Metformin from the FDA, and is updated regularly.

What is Metformin?

Metformin has active ingredients of metformin hydrochloride. It is often used in diabetes. eHealthMe is studying from 465,355 Metformin users. Check the latest studies of Metformin.

What is Underweight?

Underweight is found to be associated with 249 drugs and 383 conditions by eHealthMe. Check the latest studies of Underweight.

On Aug, 01, 2026

453,860 people reported to have side effects when taking Metformin.
Among them, 29 people (0.01%) have Underweight.

Among these 29 people:

How long have people been on Metformin when they have Underweight? *

What is the gender of people who have Underweight when taking Metformin? *

female: 51.72 %
male: 48.28 %

What is the age of people who have Underweight when taking Metformin? *

What are other drugs people take besides Metformin? *

What are other side effects people have besides Underweight? *

Drowsiness: 11 people, 37.93%
Feeling Abnormal: 9 people, 31.03%
Pain: 9 people, 31.03%
Weight Decreased: 9 people, 31.03%
Pneumonia: 8 people, 27.59%
Blood Glucose Decreased: 8 people, 27.59%
Malaise (a feeling of general discomfort or uneasiness): 6 people, 20.69%
Visual Impairment: 6 people, 20.69%
Blood Glucose Increased: 6 people, 20.69%
Weight Increased: 5 people, 17.24%

What are the existing conditions these people have? *

Asthma: 9 people, 31.03%
Pain: 5 people, 17.24%
High Blood Pressure: 4 people, 13.79%
Asthmatic Crisis: 4 people, 13.79%
Nausea (feeling of having an urge to vomit): 4 people, 13.79%
Fibromyalgia (a long-term condition which causes pain all over the body): 3 people, 10.34%
Spinal Disorder (disease of spine a back bone): 3 people, 10.34%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 2 people, 6.90%
Ankylosing Spondylitis (type of arthritis affecting the spine): 2 people, 6.90%
Bipolar Disorder (mood disorder): 2 people, 6.90%

* Approximation only. Some reports may have incomplete information.

Do you take Metformin and have Underweight?

- Check whether Underweight is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Metformin:

Metformin (465,355 reports)

Underweight treatments and more:

Underweight (2,478 reports)

Browse all side effects of Metformin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Underweight:

Underweight (249 drugs)

Browse all the conditions that are associated with Underweight:

Underweight (383 conditions)

Related publications that referenced our studies

T.Audi Yanto, I.Huang, F.Nathania Kosasih, NP Hardjo Lugito, "Nightmare and Abnormal Dreams: Rare Side Effects of Metformin?", Case Reports in Endocrinology, 2018 Jan .
Al-Hamdy RA, "Assessment of electrolytes and HbA1c in type 2 diabetic patients using metformin and evaluation of guidelines obedience regarding renal impairment", J.Thi-Qar Sci., 2015 Jan .
Wiwanitkit S, Wiwanitkit V, "Metformin and sleep disorders", Indian journal of endocrinology and metabolism, 2012 Jan .
T.Audi Yanto, I.Huang, F.Nathania Kosasih, NP Hardjo Lugito, "Nightmare and Abnormal Dreams: Rare Side Effects of Metformin?", Case Reports in Endocrinology, 2018 Jan .
Al-Hamdy RA, "Assessment of electrolytes and HbA1c in type 2 diabetic patients using metformin and evaluation of guidelines obedience regarding renal impairment", J.Thi-Qar Sci., 2015 Jan .
Wiwanitkit S, Wiwanitkit V, "Metformin and sleep disorders", Indian journal of endocrinology and metabolism, 2012 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on metformin hydrochloride (the active ingredients of Metformin) and Metformin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.