Methadose and Heart attack - a phase IV clinical study of FDA data

Summary:

Heart attack is reported as a side effect among people who take Methadose (methadone hydrochloride), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Warfarin Sodium, and have Breakthrough pain.

The phase IV clinical study analyzes which people have Heart attack when taking Methadose. It is created by eHealthMe based on reports of 4,441 people who have side effects when taking Methadose from the FDA, and is updated regularly.

What is Methadose?

Methadose has active ingredients of methadone hydrochloride. It is often used in pain. eHealthMe is studying from 5,101 Methadose users. Check the latest studies of Methadose.

What is Heart attack?

Heart attack is found to be associated with 2,474 drugs and 3,298 conditions by eHealthMe. Check the latest studies of Heart attack.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

4,441 people reported to have side effects when taking Methadose.
Among them, 15 people (0.34%) have Heart attack.

Among these 15 people:

How long have people been on Methadose when they have Heart attack? *

What is the gender of people who have Heart attack when taking Methadose? *

female: 35.71 %
male: 64.29 %

What is the age of people who have Heart attack when taking Methadose? *

What are other drugs people take besides Methadose? *

Acetaminophen And Hydrocodone Bitartrate: 4 people, 26.67%
Vicodin: 4 people, 26.67%
Furosemide: 4 people, 26.67%
Digoxin: 4 people, 26.67%
Cymbalta: 4 people, 26.67%
Coumadin: 4 people, 26.67%
Oxycontin: 4 people, 26.67%
Warfarin Sodium: 4 people, 26.67%
Cipro: 3 people, 20.00%
Clonidine: 3 people, 20.00%

What are other side effects people have besides Heart attack? *

Cardiac Failure Congestive: 5 people, 33.33%
High Blood Pressure: 5 people, 33.33%
Multiple Injuries: 5 people, 33.33%
Arrhythmias (irregular heartbeat): 5 people, 33.33%
Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 4 people, 26.67%
Oedema Peripheral (superficial swelling): 4 people, 26.67%
Pneumonia: 4 people, 26.67%
Hyperlipidaemia (presence of excess lipids in the blood): 3 people, 20.00%
Loss Of Consciousness: 3 people, 20.00%
Hypoaesthesia (reduced sense of touch or sensation): 3 people, 20.00%

What are the existing conditions these people have? *

Breakthrough Pain: 2 people, 13.33%
Wheezing (a high-pitched whistling sound made while you breath): 1 person, 6.67%
Stress And Anxiety: 1 person, 6.67%
Sciatica (a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve): 1 person, 6.67%
Neuropathy Peripheral (surface nerve damage): 1 person, 6.67%
Joint Pain: 1 person, 6.67%
Insomnia (sleeplessness): 1 person, 6.67%
High Blood Cholesterol: 1 person, 6.67%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 6.67%
Drug Dependence: 1 person, 6.67%

* Approximation only. Some reports may have incomplete information.

Do you take Methadose and have Heart attack?

- Check whether Heart attack is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Methadose:

Methadose (5,101 reports)

Heart attack treatments and more:

Heart attack (266,145 reports)

Browse all side effects of Methadose:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Heart attack:

Heart attack (2,474 drugs)

Browse all the conditions that are associated with Heart attack:

Heart attack (3,298 conditions)

Related publications that referenced our studies

McFarlane SI, "Torsades de Pointes induced by Methadone and Clonazepam Use", , 2015 Jan .
Ashkar AG, Goldberg T, Maraj I, Masters A, McFarlane SI, "Torsades De Pointes Induced by Methadone and Clonazepam Use", International Journal of Medical and Pharmaceutical Case Reports, 2015 Jan .
McFarlane, S. I. , "Torsades de Pointes induced by Methadone and Clonazepam Use", , 2014 Jan .
McFarlane SI, "Torsades de Pointes induced by Methadone and Clonazepam Use", , 2015 Jan .
Ashkar AG, Goldberg T, Maraj I, Masters A, McFarlane SI, "Torsades De Pointes Induced by Methadone and Clonazepam Use", International Journal of Medical and Pharmaceutical Case Reports, 2015 Jan .
McFarlane, S. I. , "Torsades de Pointes induced by Methadone and Clonazepam Use", , 2014 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on methadone hydrochloride (the active ingredients of Methadose) and Methadose (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.