Methimazole and Hoarseness or changing voice - a phase IV clinical study of FDA data

Summary:

Hoarseness or changing voice is reported as a side effect among people who take Methimazole (methimazole), especially for people who are female, 60+ old, have been taking the drug for 6 - 12 months also take Vitamin C, and have Endocrine ophthalmopathy.

The phase IV clinical study analyzes which people have Hoarseness or changing voice when taking Methimazole. It is created by eHealthMe based on reports of 7,420 people who have side effects when taking Methimazole from the FDA, and is updated regularly.

What is Methimazole?

Methimazole has active ingredients of methimazole. It is often used in hyperthyroidism. eHealthMe is studying from 8,016 Methimazole users. Check the latest studies of Methimazole.

What is Hoarseness or changing voice?

Hoarseness or changing voice is found to be associated with 1,786 drugs and 2,661 conditions by eHealthMe. Check the latest studies of Hoarseness or changing voice.

On Apr, 18, 2026

7,420 people reported to have side effects when taking Methimazole.
Among them, 35 people (0.47%) have Hoarseness or changing voice.

Could Methimazole cause Hoarseness or changing voice?

Among these 35 people:

How long have people been on Methimazole when they have Hoarseness or changing voice? *

What is the gender of people who have Hoarseness or changing voice when taking Methimazole? *

female: 75 %
male: 25 %

What is the age of people who have Hoarseness or changing voice when taking Methimazole? *

What are other drugs people take besides Methimazole? *

What are other side effects people have besides Hoarseness or changing voice? *

Fatigue (feeling of tiredness): 14 people, 40.00%
Weakness: 8 people, 22.86%
Headache (pain in head): 7 people, 20.00%
Nausea (feeling of having an urge to vomit): 7 people, 20.00%
Memory Loss: 7 people, 20.00%
Muscle Spasms (muscle contraction): 6 people, 17.14%
Muscle Aches (muscle pain): 6 people, 17.14%
Dyspnea (difficult or laboured breathing): 5 people, 14.29%
Weight Decreased: 5 people, 14.29%
Visual Impairment: 5 people, 14.29%

What are the existing conditions these people have? *

Endocrine Ophthalmopathy (increased water content of retroocular orbital tissues; associated with thyroid disease, usually hyperthyroidism): 5 people, 14.29%
Asthma: 4 people, 11.43%
Basedow's Disease (autoimmune disease where the thyroid is overactive, producing an excessive amount of thyroid hormones): 3 people, 8.57%
Giant Cell Tumor Of Tendon Sheath: 3 people, 8.57%
Synovitis (inflammation of the synovial membrane): 3 people, 8.57%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 2 people, 5.71%
Osteoporosis (bones weak and more likely to break): 2 people, 5.71%
Dyspnea (difficult or laboured breathing): 2 people, 5.71%
High Blood Pressure: 1 person, 2.86%
Breast Cancer: 1 person, 2.86%

* Approximation only. Some reports may have incomplete information.

Do you take Methimazole and have Hoarseness or changing voice?

- Check whether Hoarseness or changing voice is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Methimazole:

Methimazole (8,016 reports)

Browse all side effects of Methimazole:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hoarseness or changing voice:

Hoarseness or changing voice (1,786 drugs)

Browse all the conditions that are associated with Hoarseness or changing voice:

Hoarseness or changing voice (2,661 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on methimazole (the active ingredients of Methimazole) and Methimazole (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.