Methotrexate sodium and Viral haemorrhagic cystitis - a phase IV clinical study of FDA data

Summary:

Viral haemorrhagic cystitis is reported as a side effect among people who take Methotrexate sodium (methotrexate sodium), especially for people who are male, 20-29 old, have been taking the drug for < 1 month also take Iclusig, and have Acute lymphocytic leukaemia recurrent.

The phase IV clinical study analyzes which people have Viral haemorrhagic cystitis when taking Methotrexate sodium. It is created by eHealthMe based on reports of 96,366 people who have side effects when taking Methotrexate sodium from the FDA, and is updated regularly.

What is Methotrexate sodium?

Methotrexate sodium has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. eHealthMe is studying from 97,679 Methotrexate sodium users. Check the latest studies of Methotrexate sodium.

What is Viral haemorrhagic cystitis?

Viral haemorrhagic cystitis (lower urinary tract symptoms that include haematuria and irritative voiding symptoms) is found to be associated with 68 drugs and 131 conditions by eHealthMe. Check the latest studies of Viral haemorrhagic cystitis.

On Jul, 17, 2026

96,366 people reported to have side effects when taking Methotrexate sodium.
Among them, 30 people (0.03%) have Viral haemorrhagic cystitis.

Could Methotrexate sodium cause Viral haemorrhagic cystitis?

Among these 30 people:

How long have people been on Methotrexate sodium when they have Viral haemorrhagic cystitis? *

What is the gender of people who have Viral haemorrhagic cystitis when taking Methotrexate sodium? *

female: 24 %
male: 76 %

What is the age of people who have Viral haemorrhagic cystitis when taking Methotrexate sodium? *

What are other drugs people take besides Methotrexate sodium? *

Iclusig: 19 people, 63.33%
Cyclophosphamide: 5 people, 16.67%
Prednisolone: 4 people, 13.33%
Oncovin: 4 people, 13.33%
Etoposide: 4 people, 13.33%
Doxorubicin Hydrochloride: 4 people, 13.33%
Cytarabine: 4 people, 13.33%
Tacrolimus: 2 people, 6.67%
Cyclosporine: 2 people, 6.67%
Mycophenolate Mofetil: 1 person, 3.33%

What are other side effects people have besides Viral haemorrhagic cystitis? *

Cytomegalovirus Infection: 23 people, 76.67%
Post Transplant Lymphoproliferative Disorder: 22 people, 73.33%
Acute Lymphocytic Leukaemia Recurrent (cancer in which the bone marrow makes too many lymphocytes-recurrent): 20 people, 66.67%
Epstein-Barr Virus Infection: 20 people, 66.67%
Autoimmune Lymphoproliferative Syndrome (lymph proliferative disorder): 16 people, 53.33%
Ileus Paralytic (obstruction of the intestine due to paralysis of the intestinal muscles): 4 people, 13.33%
Cholecystitis (infection of gallbladder): 4 people, 13.33%
Neoplasm Recurrence (reoccurrence of tumour): 3 people, 10.00%
Bk Virus Infection: 2 people, 6.67%
Drug Ineffective: 1 person, 3.33%

What are the existing conditions these people have? *

Acute Lymphocytic Leukaemia Recurrent (cancer in which the bone marrow makes too many lymphocytes-recurrent): 23 people, 76.67%
Acute Lymphocytic Leukemia (All) (cancer of the white blood cells characterized by excess lymphoblasts): 11 people, 36.67%
Bone Marrow Conditioning Regimen: 6 people, 20.00%
Adult T-Cell Lymphoma/leukaemia (cancer of the immune system's own t-cells): 4 people, 13.33%
Graft Versus Host Disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body): 3 people, 10.00%
Engraftment Syndrome (inflammatory condition during neutrophil recovery after hematopoietic stem cell transplantation): 1 person, 3.33%
Chronic Myeloid Leukaemia (long lasting type of cancer that starts in the blood-forming cells of the bone marrow and invades the blood): 1 person, 3.33%
Acute Graft Versus Host Disease (acute complication following an allogeneic tissue/blood transplant): 1 person, 3.33%

* Approximation only. Some reports may have incomplete information.

Do you take Methotrexate sodium and have Viral haemorrhagic cystitis?

- Check whether Viral haemorrhagic cystitis is associated with a drug or a condition
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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Methotrexate sodium:

Methotrexate sodium (97,679 reports)

Browse all side effects of Methotrexate sodium:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Viral haemorrhagic cystitis:

Viral haemorrhagic cystitis (68 drugs)

Browse all the conditions that are associated with Viral haemorrhagic cystitis:

Viral haemorrhagic cystitis (131 conditions)

Related publications that referenced our studies

Henien M, Carey B, Hullah E, Sproat C, Patel V, "methotrexate-associated osteonecrosis of the jaw: A report of two cases", Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 2017 Dec .
Henien M, Carey B, Hullah E, Sproat C, Patel V, "methotrexate-associated osteonecrosis of the jaw: A report of two cases", Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 2017 Dec .

How the study uses the data?

The study uses data from the FDA. It is based on methotrexate sodium (the active ingredients of Methotrexate sodium) and Methotrexate sodium (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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