Methotrexate and Abdominal wall disorder - a phase IV clinical study of FDA data

Summary:

Abdominal wall disorder is reported as a side effect among people who take Methotrexate (methotrexate sodium), especially for people who are female, 50-59 old, have been taking the drug for 5 - 10 years also take Plaquenil, and have Atrial fibrillation/flutter.

The phase IV clinical study analyzes which people have Abdominal wall disorder when taking Methotrexate. It is created by eHealthMe based on reports of 599,650 people who have side effects when taking Methotrexate from the FDA, and is updated regularly.

What is Methotrexate?

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. eHealthMe is studying from 604,313 Methotrexate users. Check the latest studies of Methotrexate.

What is Abdominal wall disorder?

Abdominal wall disorder is found to be associated with 42 drugs and 363 conditions by eHealthMe. Check the latest studies of Abdominal wall disorder.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 20, 2026

599,650 people reported to have side effects when taking Methotrexate.
Among them, 23 people (0.0%) have Abdominal wall disorder.

Could Methotrexate cause Abdominal wall disorder?

Among these 23 people:

How long have people been on Methotrexate when they have Abdominal wall disorder? *

What is the gender of people who have Abdominal wall disorder when taking Methotrexate? *

female: 56.52 %
male: 43.48 %

What is the age of people who have Abdominal wall disorder when taking Methotrexate? *

What are other drugs people take besides Methotrexate? *

Plaquenil: 8 people, 34.78%
Morphine: 7 people, 30.43%
Xeljanz: 6 people, 26.09%
Xarelto: 6 people, 26.09%
Enbrel: 6 people, 26.09%
Prednisone: 5 people, 21.74%
Humira: 4 people, 17.39%
Hydrocodone Bitartrate And Acetaminophen: 3 people, 13.04%
Ondansetron: 3 people, 13.04%
Norco: 3 people, 13.04%

What are other side effects people have besides Abdominal wall disorder? *

Cellulitis (infection under the skin): 8 people, 34.78%
Hernia (hernia happens when part of an internal organ or tissue bulges through a weak area of muscle): 8 people, 34.78%
Abdominal Mass (localized enlargement or swelling in the human abdomen): 6 people, 26.09%
Intervertebral Disc Protrusion (spinal disc protrusion): 6 people, 26.09%
Interstitial Lung Disease: 6 people, 26.09%
Oesophageal Disorder (disease of oesophagus): 6 people, 26.09%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 6 people, 26.09%
Joint Pain: 6 people, 26.09%
Musculoskeletal Stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves): 5 people, 21.74%
Gastrointestinal Toxicity (damage to digestive tract by any substance): 5 people, 21.74%

What are the existing conditions these people have? *

Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 4 people, 17.39%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 4 people, 17.39%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 3 people, 13.04%
Osteoporosis (bones weak and more likely to break): 3 people, 13.04%
Anaplastic Large Cell Lymphoma T- And Null-Cell Types (t-cell or null-cell cancer, a type of blood cancer): 2 people, 8.70%
Stress And Anxiety: 1 person, 4.35%
Prostate Cancer: 1 person, 4.35%
Pain: 1 person, 4.35%
Non-Hodgkin's Lymphoma (malignant (cancer) cells form in the lymph system): 1 person, 4.35%
Insomnia (sleeplessness): 1 person, 4.35%

* Approximation only. Some reports may have incomplete information.

Do you take Methotrexate and have Abdominal wall disorder?

- Check whether Abdominal wall disorder is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Methotrexate:

Methotrexate (604,313 reports)

Browse all side effects of Methotrexate:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Abdominal wall disorder:

Abdominal wall disorder (42 drugs)

Browse all the conditions that are associated with Abdominal wall disorder:

Abdominal wall disorder (363 conditions)

Related publications that referenced our studies

Henien M, Carey B, Hullah E, Sproat C, Patel V, "methotrexate-associated osteonecrosis of the jaw: A report of two cases", Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 2017 Dec .
Henien M, Carey B, Hullah E, Sproat C, Patel V, "methotrexate-associated osteonecrosis of the jaw: A report of two cases", Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 2017 Dec .

How the study uses the data?

The study uses data from the FDA. It is based on methotrexate sodium (the active ingredients of Methotrexate) and Methotrexate (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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