Methotrexate and Acidosis - a phase IV clinical study of FDA data

Summary:

Acidosis is found among people who take Methotrexate, especially for people who are female, 10-19 old, have been taking the drug for < 1 month.

The phase IV clinical study analyzes which people take Methotrexate and have Acidosis. It is created by eHealthMe based on reports of 517,446 people who have side effects when taking Methotrexate from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Mar, 18, 2023

517,446 people reported to have side effects when taking Methotrexate.
Among them, 203 people (0.04%) have Acidosis.

What is Methotrexate?

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. eHealthMe is studying from 521,927 Methotrexate users for its effectiveness, alternative drugs and more.

What is Acidosis?

Acidosis (build-up of carbon dioxide in the blood) is found to be associated with 1,728 drugs and 983 conditions by eHealthMe.

Number of Methotrexate and Acidosis reports submitted per year:

* Approximation only. Some reports may have incomplete information.

Do you take Methotrexate and have Acidosis?

Check whether Acidosis is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related publications that referenced our studies

Henien M, Carey B, Hullah E, Sproat C, Patel V, "methotrexate-associated osteonecrosis of the jaw: A report of two cases", Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 2017 Dec .

Related studies

How severe was Acidosis and when was it recovered:

Acidosis in Methotrexate

Expand to all the drugs that have ingredients of methotrexate sodium:

Acidosis and drugs with ingredients of methotrexate sodium (157 reports)

Alternative drugs to, pros and cons of Methotrexate:

Methotrexate (521,927 reports)

Common Methotrexate side effects:

Drug ineffective: 104,668 reports
Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints): 52,705 reports
Joint pain: 45,719 reports
Pain: 44,785 reports
Fatigue (feeling of tiredness): 36,266 reports
Rashes (redness): 30,738 reports
Joint swelling: 29,058 reports
Headache (pain in head): 25,739 reports

Browse all side effects of Methotrexate:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Acidosis treatments and more:

Acidosis (8,690 reports)

COVID vaccines that are related to Acidosis:

Common drugs associated with Acidosis:

All the drugs that are associated with Acidosis:

Acidosis (1,728 drugs)

Common conditions associated with Acidosis:

All the conditions that are associated with Acidosis:

Acidosis (983 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on methotrexate sodium (the active ingredients of Methotrexate) and Methotrexate (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.