Methotrexate and Acute polyneuropathy - a phase IV clinical study of FDA data

Summary:

Acute polyneuropathy is reported as a side effect among people who take Methotrexate (methotrexate sodium), especially for people who are female, 10-19 old, have been taking the drug for 2 - 5 years also take Prednisone, and have Ankylosing spondylitis.

The phase IV clinical study analyzes which people have Acute polyneuropathy when taking Methotrexate. It is created by eHealthMe based on reports of 599,650 people who have side effects when taking Methotrexate from the FDA, and is updated regularly.

What is Methotrexate?

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. eHealthMe is studying from 604,314 Methotrexate users. Check the latest studies of Methotrexate.

What is Acute polyneuropathy?

Acute polyneuropathy (acute illness where sensory and motor nerves of the peripheral nervous system are affected) is found to be associated with 31 drugs and 96 conditions by eHealthMe. Check the latest studies of Acute polyneuropathy.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

599,650 people reported to have side effects when taking Methotrexate.
Among them, 15 people (0.0%) have Acute polyneuropathy.

Could Methotrexate cause Acute polyneuropathy?

Among these 15 people:

How long have people been on Methotrexate when they have Acute polyneuropathy? *

What is the gender of people who have Acute polyneuropathy when taking Methotrexate? *

female: 53.33 %
male: 46.67 %

What is the age of people who have Acute polyneuropathy when taking Methotrexate? *

What are other drugs people take besides Methotrexate? *

What are other side effects people have besides Acute polyneuropathy? *

Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect): 5 people, 33.33%
Febrile Neutropenia (fever with reduced white blood cells): 4 people, 26.67%
Guillain-Barre Syndrome (the body's immune system attacks its peripheral nervous system): 4 people, 26.67%
Osteoporosis (bones weak and more likely to break): 3 people, 20.00%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 3 people, 20.00%
Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it): 3 people, 20.00%
Miller Fisher Syndrome (a rare disorder that is characterized by abnormal muscle coordination): 3 people, 20.00%
High Blood Pressure: 3 people, 20.00%
Citrobacter Sepsis (infection by citrobacter (bacteria) in blood): 3 people, 20.00%
Gamma-Glutamyltransferase Increased: 3 people, 20.00%

What are the existing conditions these people have? *

B Precursor Type Acute Leukaemia (lymphoid cancer): 3 people, 20.00%
Ankylosing Spondylitis (type of arthritis affecting the spine): 3 people, 20.00%
Pain: 2 people, 13.33%
Non-Hodgkin's Lymphoma (malignant (cancer) cells form in the lymph system): 1 person, 6.67%
Mixed Connective Tissue Disease (an autoimmune disease, in which the body's defence system attacks itself): 1 person, 6.67%
Juvenile Arthritis (arthritis-related condition that develops in children or teenagers): 1 person, 6.67%
Inflammatory Bowel Disease: 1 person, 6.67%
High Blood Pressure: 1 person, 6.67%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 1 person, 6.67%
Bone Marrow Conditioning Regimen: 1 person, 6.67%

* Approximation only. Some reports may have incomplete information.

Do you take Methotrexate and have Acute polyneuropathy?

- Check whether Acute polyneuropathy is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Methotrexate:

Methotrexate (604,314 reports)

Browse all side effects of Methotrexate:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Acute polyneuropathy:

Acute polyneuropathy (31 drugs)

Browse all the conditions that are associated with Acute polyneuropathy:

Acute polyneuropathy (96 conditions)

Related publications that referenced our studies

Henien M, Carey B, Hullah E, Sproat C, Patel V, "methotrexate-associated osteonecrosis of the jaw: A report of two cases", Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 2017 Dec .
Henien M, Carey B, Hullah E, Sproat C, Patel V, "methotrexate-associated osteonecrosis of the jaw: A report of two cases", Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 2017 Dec .

How the study uses the data?

The study uses data from the FDA. It is based on methotrexate sodium (the active ingredients of Methotrexate) and Methotrexate (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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