Methotrexate and Electrocardiogram qrs complex prolonged - a phase IV clinical study of FDA data

Summary:

Electrocardiogram qrs complex prolonged is reported as a side effect among people who take Methotrexate (methotrexate sodium), especially for people who are male, 20-29 old, have been taking the drug for 1 - 2 years also take Folic Acid, and have B precursor type acute leukaemia.

The phase IV clinical study analyzes which people have Electrocardiogram qrs complex prolonged when taking Methotrexate. It is created by eHealthMe based on reports of 599,650 people who have side effects when taking Methotrexate from the FDA, and is updated regularly.

What is Methotrexate?

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. eHealthMe is studying from 604,313 Methotrexate users. Check the latest studies of Methotrexate.

What is Electrocardiogram qrs complex prolonged?

Electrocardiogram qrs complex prolonged is found to be associated with 321 drugs and 548 conditions by eHealthMe. Check the latest studies of Electrocardiogram qrs complex prolonged.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 24, 2026

599,650 people reported to have side effects when taking Methotrexate.
Among them, 21 people (0.0%) have Electrocardiogram qrs complex prolonged.

Could Methotrexate cause Electrocardiogram qrs complex prolonged?

Among these 21 people:

How long have people been on Methotrexate when they have Electrocardiogram qrs complex prolonged? *

What is the gender of people who have Electrocardiogram qrs complex prolonged when taking Methotrexate? *

female: 31.58 %
male: 68.42 %

What is the age of people who have Electrocardiogram qrs complex prolonged when taking Methotrexate? *

What are other drugs people take besides Methotrexate? *

Folic Acid: 5 people, 23.81%
Hydroxychloroquine Sulfate: 4 people, 19.05%
Dexamethasone: 4 people, 19.05%
Mercaptopurine: 4 people, 19.05%
Prednisolone: 3 people, 14.29%
Alcohol: 2 people, 9.52%
Azathioprine: 2 people, 9.52%
Cyclophosphamide: 2 people, 9.52%
Cytarabine: 2 people, 9.52%
Lorazepam: 2 people, 9.52%

What are other side effects people have besides Electrocardiogram qrs complex prolonged? *

Ventricular Tachycardia (rapid heartbeat that originates in one of the lower chambers (the ventricles) of the heart): 15 people, 71.43%
Electrocardiogram Qt Prolonged: 12 people, 57.14%
Hypotension (abnormally low blood pressure): 11 people, 52.38%
Nausea (feeling of having an urge to vomit): 10 people, 47.62%
Hypokalemia (low potassium): 9 people, 42.86%
Nausea And Vomiting: 9 people, 42.86%
Drowsiness: 8 people, 38.10%
Suicide Attempt: 8 people, 38.10%
Weakness: 7 people, 33.33%
Blood Lactic Acid Increased: 4 people, 19.05%

What are the existing conditions these people have? *

Suicide Attempt: 2 people, 9.52%
B Precursor Type Acute Leukaemia (lymphoid cancer): 2 people, 9.52%
Poisoning Deliberate: 1 person, 4.76%
Overdose: 1 person, 4.76%
Folate Deficiency (lack of folic acid): 1 person, 4.76%
Electrocardiogram Qt Prolonged: 1 person, 4.76%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 1 person, 4.76%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 1 person, 4.76%
Arrhythmias (irregular heartbeat): 1 person, 4.76%

* Approximation only. Some reports may have incomplete information.

Do you take Methotrexate and have Electrocardiogram qrs complex prolonged?

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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Methotrexate:

Methotrexate (604,313 reports)

Electrocardiogram qrs complex prolonged treatments and more:

Electrocardiogram qrs complex prolonged (5,444 reports)

How severe was Electrocardiogram qrs complex prolonged and when was it recovered:

Electrocardiogram qrs complex prolonged in Methotrexate

Expand to all the drugs that have ingredients of methotrexate sodium:

Electrocardiogram qrs complex prolonged and drugs with ingredients of methotrexate sodium (21 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Methotrexate:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Electrocardiogram qrs complex prolonged:

Electrocardiogram qrs complex prolonged (321 drugs)

Browse all the conditions that are associated with Electrocardiogram qrs complex prolonged:

Electrocardiogram qrs complex prolonged (548 conditions)

Related publications that referenced our studies

Henien M, Carey B, Hullah E, Sproat C, Patel V, "methotrexate-associated osteonecrosis of the jaw: A report of two cases", Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 2017 Dec .
Henien M, Carey B, Hullah E, Sproat C, Patel V, "methotrexate-associated osteonecrosis of the jaw: A report of two cases", Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 2017 Dec .

How the study uses the data?

The study uses data from the FDA. It is based on methotrexate sodium (the active ingredients of Methotrexate) and Methotrexate (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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