Methotrexate and Fatigue - from FDA reports


Fatigue is found among people who take Methotrexate, especially for people who are female, 60+ old , have been taking the drug for 1 - 6 months, also take medication Enbrel, and have Psoriatic arthropathy. This review analyzes which people have Fatigue with Methotrexate. It is created by eHealthMe based on reports of 231,270 people who have side effects when taking Methotrexate from FDA, and is updated regularly.



On Jul, 15, 2018

231,270 people reported to have side effects when taking Methotrexate.
Among them, 9,957 people (4.31%) have Fatigue


Number of reports submitted per year:

Could Methotrexate cause Fatigue?

Time on Methotrexate when people have Fatigue *:

  • < 1 month: 18.23 %
  • 1 - 6 months: 19.77 %
  • 6 - 12 months: 10.94 %
  • 1 - 2 years: 13.82 %
  • 2 - 5 years: 17.47 %
  • 5 - 10 years: 12.48 %
  • 10+ years: 7.29 %

Gender of people who have Fatigue when taking Methotrexate *:

  • female: 78.7 %
  • male: 21.3 %

Age of people who have Fatigue when taking Methotrexate *:

  • 0-1: 0.18 %
  • 2-9: 1.3 %
  • 10-19: 2.82 %
  • 20-29: 2.91 %
  • 30-39: 7.36 %
  • 40-49: 16.28 %
  • 50-59: 28.26 %
  • 60+: 40.88 %

Top conditions involved for these people *:

  1. Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 820 people, 8.24%
  2. Pain: 626 people, 6.29%
  3. High Blood Pressure: 514 people, 5.16%
  4. Psoriasis (immune-mediated disease that affects the skin): 431 people, 4.33%
  5. High Blood Cholesterol: 333 people, 3.34%

Top co-used drugs for these people *:

  1. Enbrel: 3,254 people, 32.68%
  2. Humira: 2,660 people, 26.71%
  3. Folic Acid: 1,836 people, 18.44%
  4. Prednisone: 1,079 people, 10.84%
  5. Plaquenil: 985 people, 9.89%

Top other side effects for these people *:

  1. Pain: 1,929 people, 19.37%
  2. Joint Pain: 1,904 people, 19.12%
  3. Nausea (feeling of having an urge to vomit): 1,815 people, 18.23%
  4. Headache (pain in head): 1,549 people, 15.56%
  5. Weakness: 1,516 people, 15.23%

* Approximation only. Some reports may have incomplete information.

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