Methotrexate and Fatigue - from FDA reports


Fatigue is found among people who take Methotrexate, especially for people who are female, 60+ old , have been taking the drug for 1 - 6 months, also take medication Enbrel, and have Psoriatic arthropathy. This study is created by eHealthMe based on reports of 289,603 people who have side effects when taking Methotrexate from FDA, and is updated regularly.

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On Oct, 12, 2018

289,603 people reported to have side effects when taking Methotrexate.
Among them, 13,033 people (4.5%) have Fatigue


Number of reports submitted per year:

Could Methotrexate cause Fatigue?

Time on Methotrexate when people have Fatigue *:

Gender of people who have Fatigue when taking Methotrexate *:

  • female: 79.64 %
  • male: 20.36 %

Age of people who have Fatigue when taking Methotrexate *:

Top conditions involved for these people *:

  1. Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 1,000 people, 7.67%
  2. Pain: 755 people, 5.79%
  3. High Blood Pressure: 599 people, 4.60%
  4. Psoriasis (immune-mediated disease that affects the skin): 561 people, 4.30%
  5. High Blood Cholesterol: 384 people, 2.95%

Click here to view more results or personalize the results to your gender and age

Top co-used drugs for these people *:

  1. Enbrel: 4,476 people, 34.34%
  2. Humira: 3,673 people, 28.18%
  3. Folic Acid: 1,836 people, 14.09%
  4. Plaquenil: 1,468 people, 11.26%
  5. Actemra: 1,360 people, 10.44%

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Top other side effects for these people *:

  1. Pain: 2,809 people, 21.55%
  2. Joint Pain: 2,640 people, 20.26%
  3. Nausea (feeling of having an urge to vomit): 2,369 people, 18.18%
  4. Drug Ineffective: 2,238 people, 17.17%
  5. Headache (pain in head): 1,980 people, 15.19%

Click here to view more results or personalize the results to your gender and age

* Approximation only. Some reports may have incomplete information.

FDA reports used in this study



Do you have Fatigue while taking Methotrexate?


You are not alone:




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NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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