Methotrexate and Gallbladder non-functioning - a phase IV clinical study of FDA data

Summary:

Gallbladder non-functioning is reported as a side effect among people who take Methotrexate (methotrexate sodium), especially for people who are female, 50-59 old, have been taking the drug for 1 - 6 months also take Humira, and have Diabetes.

The phase IV clinical study analyzes which people have Gallbladder non-functioning when taking Methotrexate. It is created by eHealthMe based on reports of 599,650 people who have side effects when taking Methotrexate from the FDA, and is updated regularly.

What is Methotrexate?

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. eHealthMe is studying from 604,307 Methotrexate users. Check the latest studies of Methotrexate.

What is Gallbladder non-functioning?

Gallbladder non-functioning is found to be associated with 132 drugs and 440 conditions by eHealthMe. Check the latest studies of Gallbladder non-functioning.

On Dec, 07, 2025

599,650 people reported to have side effects when taking Methotrexate.
Among them, 17 people (0.0%) have Gallbladder non-functioning.

Could Methotrexate cause Gallbladder non-functioning?

Among these 17 people:

How long have people been on Methotrexate when they have Gallbladder non-functioning? *

What is the gender of people who have Gallbladder non-functioning when taking Methotrexate? *

female: 76.47 %
male: 23.53 %

What is the age of people who have Gallbladder non-functioning when taking Methotrexate? *

What are other drugs people take besides Methotrexate? *

What are other side effects people have besides Gallbladder non-functioning? *

Gallstones (stone formation by bile component): 6 people, 35.29%
Pain: 4 people, 23.53%
Hepatic Enzyme Increased: 4 people, 23.53%
Rhinorrhea (watery mucus discharge from the nose): 4 people, 23.53%
Gingival Bleeding (bleeding gums): 3 people, 17.65%
Oropharyngeal Pain: 3 people, 17.65%
Hepatic Cyst: 3 people, 17.65%
Cholecystitis Infective (infection of gallbladder capable to infect other organs): 3 people, 17.65%
Pneumonia: 3 people, 17.65%
Nausea (feeling of having an urge to vomit): 3 people, 17.65%

What are the existing conditions these people have? *

Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 4 people, 23.53%
Diabetes: 4 people, 23.53%
Pain: 3 people, 17.65%
Ankylosing Spondylitis (type of arthritis affecting the spine): 2 people, 11.76%
High Blood Cholesterol: 2 people, 11.76%
Back Pain: 2 people, 11.76%
Osteoporosis (bones weak and more likely to break): 2 people, 11.76%
Depression: 2 people, 11.76%
Birth Control: 1 person, 5.88%
Herpes Zoster: 1 person, 5.88%

* Approximation only. Some reports may have incomplete information.

Do you take Methotrexate and have Gallbladder non-functioning?

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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Methotrexate:

Methotrexate (604,307 reports)

Browse all side effects of Methotrexate:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Gallbladder non-functioning:

Gallbladder non-functioning (132 drugs)

Browse all the conditions that are associated with Gallbladder non-functioning:

Gallbladder non-functioning (440 conditions)

Drugs similar to Methotrexate and Gallbladder non-functioning :

Related publications that referenced our studies

Henien M, Carey B, Hullah E, Sproat C, Patel V, "methotrexate-associated osteonecrosis of the jaw: A report of two cases", Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 2017 Dec .
Henien M, Carey B, Hullah E, Sproat C, Patel V, "methotrexate-associated osteonecrosis of the jaw: A report of two cases", Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 2017 Dec .

How the study uses the data?

The study uses data from the FDA. It is based on methotrexate sodium (the active ingredients of Methotrexate) and Methotrexate (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.