Methotrexate and Hypoprothrombinaemia - a phase IV clinical study of FDA data

Summary:

Hypoprothrombinaemia is reported as a side effect among people who take Methotrexate (methotrexate sodium), especially for people who are male, 10-19 old, have been taking the drug for < 1 month also take Oncovin, and have Chemotherapy cardiotoxicity attenuation.

The phase IV clinical study analyzes which people have Hypoprothrombinaemia when taking Methotrexate. It is created by eHealthMe based on reports of 599,650 people who have side effects when taking Methotrexate from the FDA, and is updated regularly.

What is Methotrexate?

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. eHealthMe is studying from 604,313 Methotrexate users. Check the latest studies of Methotrexate.

What is Hypoprothrombinaemia?

Hypoprothrombinaemia (blood disorder in which a deficiency of prothrombin (factor ii) results in impaired blood clotting) is found to be associated with 64 drugs and 124 conditions by eHealthMe. Check the latest studies of Hypoprothrombinaemia.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 20, 2026

599,650 people reported to have side effects when taking Methotrexate.
Among them, 13 people (0.0%) have Hypoprothrombinaemia.

Could Methotrexate cause Hypoprothrombinaemia?

Among these 13 people:

How long have people been on Methotrexate when they have Hypoprothrombinaemia? *

What is the gender of people who have Hypoprothrombinaemia when taking Methotrexate? *

female: 15.38 %
male: 84.62 %

What is the age of people who have Hypoprothrombinaemia when taking Methotrexate? *

What are other drugs people take besides Methotrexate? *

What are other side effects people have besides Hypoprothrombinaemia? *

Pneumonia: 4 people, 30.77%
Febrile Neutropenia (fever with reduced white blood cells): 3 people, 23.08%
Urine Output - Decreased: 3 people, 23.08%
Bone Marrow Failure: 3 people, 23.08%
Antithrombin Iii Decreased: 3 people, 23.08%
Disseminated Intravascular Coagulation (systemic activation of blood coagulation): 3 people, 23.08%
Oral Candidiasis (fungal infection of mouth): 2 people, 15.38%
Oesophageal Candidiasis (fungal infection of oesophagus): 2 people, 15.38%
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets): 2 people, 15.38%
Appetite Disorder (abnormal eating habits): 1 person, 7.69%

What are the existing conditions these people have? *

Venoocclusive Liver Disease (small veins in the liver are obstructed): 3 people, 23.08%
Sedation: 3 people, 23.08%
Nausea (feeling of having an urge to vomit): 3 people, 23.08%
Gastritis (inflammation of stomach): 3 people, 23.08%
Fever: 3 people, 23.08%
Chemotherapy Cardiotoxicity Attenuation: 3 people, 23.08%
Helicobacter Infection (helicobacter pylori (h. pylori) infects stomach): 2 people, 15.38%
Attention Deficit Hyperactivity Disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness): 1 person, 7.69%
Abscess Neck (neck abscesses): 1 person, 7.69%

* Approximation only. Some reports may have incomplete information.

Do you take Methotrexate and have Hypoprothrombinaemia?

- Check whether Hypoprothrombinaemia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Methotrexate:

Methotrexate (604,313 reports)

Browse all side effects of Methotrexate:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hypoprothrombinaemia:

Hypoprothrombinaemia (64 drugs)

Browse all the conditions that are associated with Hypoprothrombinaemia:

Hypoprothrombinaemia (124 conditions)

Related publications that referenced our studies

Henien M, Carey B, Hullah E, Sproat C, Patel V, "methotrexate-associated osteonecrosis of the jaw: A report of two cases", Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 2017 Dec .
Henien M, Carey B, Hullah E, Sproat C, Patel V, "methotrexate-associated osteonecrosis of the jaw: A report of two cases", Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 2017 Dec .

How the study uses the data?

The study uses data from the FDA. It is based on methotrexate sodium (the active ingredients of Methotrexate) and Methotrexate (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.