Methotrexate and Ileal perforation - a phase IV clinical study of FDA data

Summary:

Ileal perforation is reported as a side effect among people who take Methotrexate (methotrexate sodium), especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months also take Humira, and have Crohn's disease.

The phase IV clinical study analyzes which people have Ileal perforation when taking Methotrexate. It is created by eHealthMe based on reports of 599,650 people who have side effects when taking Methotrexate from the FDA, and is updated regularly.

What is Methotrexate?

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. eHealthMe is studying from 604,312 Methotrexate users. Check the latest studies of Methotrexate.

What is Ileal perforation?

Ileal perforation is found to be associated with 100 drugs and 258 conditions by eHealthMe. Check the latest studies of Ileal perforation.

On Jul, 26, 2026

599,650 people reported to have side effects when taking Methotrexate.
Among them, 51 people (0.01%) have Ileal perforation.

Could Methotrexate cause Ileal perforation?

Among these 51 people:

How long have people been on Methotrexate when they have Ileal perforation? *

What is the gender of people who have Ileal perforation when taking Methotrexate? *

female: 68.89 %
male: 31.11 %

What is the age of people who have Ileal perforation when taking Methotrexate? *

What are other drugs people take besides Methotrexate? *

What are other side effects people have besides Ileal perforation? *

Peritonitis (inflammation of the peritoneum, the thin tissue that lines the inner wall of the abdomen and covers most of the abdominal organs): 16 people, 31.37%
Intestinal Obstruction: 10 people, 19.61%
Drug Ineffective: 8 people, 15.69%
Non-Hodgkin's Lymphoma (malignant (cancer) cells form in the lymph system): 7 people, 13.73%
Fever: 7 people, 13.73%
Rashes (redness): 6 people, 11.76%
Respiratory Acidosis (respiratory failure or ventilatory failure, causes the ph of blood and other bodily fluids to decrease): 6 people, 11.76%
Septic Shock (shock due to blood infection): 6 people, 11.76%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 6 people, 11.76%
Abdominal Pain: 6 people, 11.76%

What are the existing conditions these people have? *

Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 8 people, 15.69%
Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 2 people, 3.92%
Immunodeficiency Disorders: 2 people, 3.92%
Depression: 2 people, 3.92%
Burkitt Lymphoma (cancer of the lymphatic system): 2 people, 3.92%
T-Cell Lymphoma (a blood cell cancer): 1 person, 1.96%
Malignant Melanoma (skin cancer rises from melancytes): 1 person, 1.96%
Juvenile Rheumatoid Arthritis (joint inflammation in children due to systemic disease): 1 person, 1.96%
Juvenile Arthritis (arthritis-related condition that develops in children or teenagers): 1 person, 1.96%
B Precursor Type Acute Leukaemia (lymphoid cancer): 1 person, 1.96%

* Approximation only. Some reports may have incomplete information.

Do you take Methotrexate and have Ileal perforation?

- Check whether Ileal perforation is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Methotrexate:

Methotrexate (604,312 reports)

Browse all side effects of Methotrexate:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Ileal perforation:

Ileal perforation (100 drugs)

Browse all the conditions that are associated with Ileal perforation:

Ileal perforation (258 conditions)

Related publications that referenced our studies

Henien M, Carey B, Hullah E, Sproat C, Patel V, "methotrexate-associated osteonecrosis of the jaw: A report of two cases", Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 2017 Dec .
Herrin MA, Rubinstein JC, Christison-Lagay ER, "Temsirolimus therapy and small bowel perforation in a pediatric patient with Clostridium septicum bacteremia", Journal of Pediatric Surgery Case Reports, 2015 Aug .
Henien M, Carey B, Hullah E, Sproat C, Patel V, "methotrexate-associated osteonecrosis of the jaw: A report of two cases", Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 2017 Dec .
Herrin MA, Rubinstein JC, Christison-Lagay ER, "Temsirolimus therapy and small bowel perforation in a pediatric patient with Clostridium septicum bacteremia", Journal of Pediatric Surgery Case Reports, 2015 Aug .

How the study uses the data?

The study uses data from the FDA. It is based on methotrexate sodium (the active ingredients of Methotrexate) and Methotrexate (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.