Methotrexate and Mean cell volume abnormal - a phase IV clinical study of FDA data

Summary:

Mean cell volume abnormal is reported as a side effect among people who take Methotrexate (methotrexate sodium), especially for people who are female, 60+ old, also take Folic Acid, and have Type 2 diabetes.

The phase IV clinical study analyzes which people have Mean cell volume abnormal when taking Methotrexate. It is created by eHealthMe based on reports of 599,650 people who have side effects when taking Methotrexate from the FDA, and is updated regularly.

What is Methotrexate?

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. eHealthMe is studying from 604,312 Methotrexate users. Check the latest studies of Methotrexate.

What is Mean cell volume abnormal?

Mean cell volume abnormal (abnormal of the average red blood cell volume) is found to be associated with 178 drugs and 184 conditions by eHealthMe. Check the latest studies of Mean cell volume abnormal.

On Jul, 26, 2026

599,650 people reported to have side effects when taking Methotrexate.
Among them, 36 people (0.01%) have Mean cell volume abnormal.

Could Methotrexate cause Mean cell volume abnormal?

Among these 36 people:

What is the gender of people who have Mean cell volume abnormal when taking Methotrexate? *

female: 56.25 %
male: 43.75 %

What is the age of people who have Mean cell volume abnormal when taking Methotrexate? *

What are other drugs people take besides Methotrexate? *

What are other side effects people have besides Mean cell volume abnormal? *

Fatigue (feeling of tiredness): 17 people, 47.22%
Rashes (redness): 12 people, 33.33%
Chills (felling of cold): 12 people, 33.33%
Musculoskeletal Stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves): 12 people, 33.33%
Pain: 11 people, 30.56%
Weight Decreased: 11 people, 30.56%
Aspartate Aminotransferase Increased: 11 people, 30.56%
Dyspnea (difficult or laboured breathing): 11 people, 30.56%
Haemoglobin Decreased: 10 people, 27.78%
Dizziness: 10 people, 27.78%

What are the existing conditions these people have? *

Type 2 Diabetes: 8 people, 22.22%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 7 people, 19.44%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 2 people, 5.56%
Osteoporosis (bones weak and more likely to break): 2 people, 5.56%
Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 1 person, 2.78%
Polymyositis (inflammatory muscle disease that causes weakness of the skeletal muscles): 1 person, 2.78%

* Approximation only. Some reports may have incomplete information.

Do you take Methotrexate and have Mean cell volume abnormal?

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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Methotrexate:

Methotrexate (604,312 reports)

Browse all side effects of Methotrexate:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Mean cell volume abnormal:

Mean cell volume abnormal (178 drugs)

Browse all the conditions that are associated with Mean cell volume abnormal:

Mean cell volume abnormal (184 conditions)

Related publications that referenced our studies

Henien M, Carey B, Hullah E, Sproat C, Patel V, "methotrexate-associated osteonecrosis of the jaw: A report of two cases", Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 2017 Dec .
Henien M, Carey B, Hullah E, Sproat C, Patel V, "methotrexate-associated osteonecrosis of the jaw: A report of two cases", Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 2017 Dec .

How the study uses the data?

The study uses data from the FDA. It is based on methotrexate sodium (the active ingredients of Methotrexate) and Methotrexate (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.