Methotrexate and Oral pruritus - a phase IV clinical study of FDA data

Summary:

Oral pruritus is reported as a side effect among people who take Methotrexate (methotrexate sodium), especially for people who are female, 60+ old, have been taking the drug for 2 - 5 years also take Acetaminophen, and have Asthma.

The phase IV clinical study analyzes which people have Oral pruritus when taking Methotrexate. It is created by eHealthMe based on reports of 599,650 people who have side effects when taking Methotrexate from the FDA, and is updated regularly.

What is Methotrexate?

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. eHealthMe is studying from 604,312 Methotrexate users. Check the latest studies of Methotrexate.

What is Oral pruritus?

Oral pruritus (itching in mouth) is found to be associated with 246 drugs and 374 conditions by eHealthMe. Check the latest studies of Oral pruritus.

On Jul, 12, 2026

599,650 people reported to have side effects when taking Methotrexate.
Among them, 79 people (0.01%) have Oral pruritus.

Among these 79 people:

How long have people been on Methotrexate when they have Oral pruritus? *

What is the gender of people who have Oral pruritus when taking Methotrexate? *

female: 89.83 %
male: 10.17 %

What is the age of people who have Oral pruritus when taking Methotrexate? *

What are other drugs people take besides Methotrexate? *

Acetaminophen: 26 people, 32.91%
Synthroid: 19 people, 24.05%
Methylprednisolone: 18 people, 22.78%
Folic Acid: 17 people, 21.52%
Rituxan: 16 people, 20.25%
Prednisone: 15 people, 18.99%
Celebrex: 14 people, 17.72%
Humira: 14 people, 17.72%
Diphenhydramine Hydrochloride: 14 people, 17.72%
Pantoprazole Sodium: 12 people, 15.19%

What are other side effects people have besides Oral pruritus? *

High Blood Pressure: 40 people, 50.63%
Infusion Related Reaction: 29 people, 36.71%
Weight Decreased: 28 people, 35.44%
Oxygen Saturation Decreased: 25 people, 31.65%
Heart Rate Increased: 24 people, 30.38%
Blood Pressure Fluctuation: 23 people, 29.11%
Hypotension (abnormally low blood pressure): 23 people, 29.11%
Itching: 22 people, 27.85%
Stress And Anxiety: 19 people, 24.05%
Pain In Extremity: 17 people, 21.52%

What are the existing conditions these people have? *

Polyarthritis (arthritis which involves 5 or more joints simultaneously): 11 people, 13.92%
Asthma: 11 people, 13.92%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 9 people, 11.39%
Psoriasis (immune-mediated disease that affects the skin): 3 people, 3.80%
Pain: 3 people, 3.80%
Osteoporosis (bones weak and more likely to break): 3 people, 3.80%
Cardiac Disorder: 3 people, 3.80%
Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 2 people, 2.53%
Thyroid Diseases: 2 people, 2.53%
Arrhythmias (irregular heartbeat): 2 people, 2.53%

* Approximation only. Some reports may have incomplete information.

Do you take Methotrexate and have Oral pruritus?

- Check whether Oral pruritus is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Methotrexate:

Methotrexate (604,312 reports)

Oral pruritus treatments and more:

Oral pruritus (2,343 reports)

Browse all side effects of Methotrexate:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Oral pruritus:

Oral pruritus (246 drugs)

Browse all the conditions that are associated with Oral pruritus:

Oral pruritus (374 conditions)

Related publications that referenced our studies

Henien M, Carey B, Hullah E, Sproat C, Patel V, "methotrexate-associated osteonecrosis of the jaw: A report of two cases", Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 2017 Dec .
Henien M, Carey B, Hullah E, Sproat C, Patel V, "methotrexate-associated osteonecrosis of the jaw: A report of two cases", Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 2017 Dec .

How the study uses the data?

The study uses data from the FDA. It is based on methotrexate sodium (the active ingredients of Methotrexate) and Methotrexate (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.