Methotrexate and Sciatic nerve injury - a phase IV clinical study of FDA data

Summary:

Sciatic nerve injury is reported as a side effect among people who take Methotrexate (methotrexate sodium), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Enbrel, and have Psoriatic arthropathy.

The phase IV clinical study analyzes which people have Sciatic nerve injury when taking Methotrexate. It is created by eHealthMe based on reports of 599,650 people who have side effects when taking Methotrexate from the FDA, and is updated regularly.

What is Methotrexate?

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. eHealthMe is studying from 604,313 Methotrexate users. Check the latest studies of Methotrexate.

What is Sciatic nerve injury?

Sciatic nerve injury is found to be associated with 148 drugs and 299 conditions by eHealthMe. Check the latest studies of Sciatic nerve injury.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 25, 2026

599,650 people reported to have side effects when taking Methotrexate.
Among them, 28 people (0.0%) have Sciatic nerve injury.

Could Methotrexate cause Sciatic nerve injury?

Among these 28 people:

How long have people been on Methotrexate when they have Sciatic nerve injury? *

What is the gender of people who have Sciatic nerve injury when taking Methotrexate? *

female: 76.92 %
male: 23.08 %

What is the age of people who have Sciatic nerve injury when taking Methotrexate? *

What are other drugs people take besides Methotrexate? *

What are other side effects people have besides Sciatic nerve injury? *

Drug Ineffective: 10 people, 35.71%
Pain In Extremity: 9 people, 32.14%
Joint Pain: 8 people, 28.57%
Weight Decreased: 7 people, 25.00%
Sciatica (a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve): 6 people, 21.43%
Fall: 6 people, 21.43%
Dry Skin: 5 people, 17.86%
Osteitis (a general term for inflammation of bone): 5 people, 17.86%
Varicose Ulceration: 5 people, 17.86%
Impaired Healing: 5 people, 17.86%

What are the existing conditions these people have? *

Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 4 people, 14.29%
Psoriasis (immune-mediated disease that affects the skin): 2 people, 7.14%
Prostatic Disorder: 2 people, 7.14%
High Blood Pressure: 2 people, 7.14%
High Blood Cholesterol: 2 people, 7.14%
Gastritis (inflammation of stomach): 2 people, 7.14%
Pneumonia: 1 person, 3.57%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 1 person, 3.57%

* Approximation only. Some reports may have incomplete information.

Do you take Methotrexate and have Sciatic nerve injury?

- Check whether Sciatic nerve injury is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Methotrexate:

Methotrexate (604,313 reports)

Browse all side effects of Methotrexate:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Sciatic nerve injury:

Sciatic nerve injury (148 drugs)

Browse all the conditions that are associated with Sciatic nerve injury:

Sciatic nerve injury (299 conditions)

Related publications that referenced our studies

Henien M, Carey B, Hullah E, Sproat C, Patel V, "methotrexate-associated osteonecrosis of the jaw: A report of two cases", Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 2017 Dec .
Henien M, Carey B, Hullah E, Sproat C, Patel V, "methotrexate-associated osteonecrosis of the jaw: A report of two cases", Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 2017 Dec .

How the study uses the data?

The study uses data from the FDA. It is based on methotrexate sodium (the active ingredients of Methotrexate) and Methotrexate (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.