Methotrexate and Ttp - a phase IV clinical study of FDA data

Summary:

Ttp is reported as a side effect among people who take Methotrexate (methotrexate sodium), especially for people who are female, 50-59 old, have been taking the drug for 5 - 10 years also take Cyclosporine, and have Constipation.

The phase IV clinical study analyzes which people have Ttp when taking Methotrexate. It is created by eHealthMe based on reports of 599,650 people who have side effects when taking Methotrexate from the FDA, and is updated regularly.

What is Methotrexate?

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. eHealthMe is studying from 604,298 Methotrexate users. Check the latest studies of Methotrexate.

What is Ttp?

Ttp is found to be associated with 987 drugs and 819 conditions by eHealthMe. Check the latest studies of Ttp.

On Jul, 28, 2025

599,650 people reported to have side effects when taking Methotrexate.
Among them, 104 people (0.02%) have Ttp.

Among these 104 people:

How long have people been on Methotrexate when they have Ttp? *

What is the gender of people who have Ttp when taking Methotrexate? *

female: 60 %
male: 40 %

What is the age of people who have Ttp when taking Methotrexate? *

What are other drugs people take besides Methotrexate? *

What are other side effects people have besides Ttp? *

Haemolytic Uraemic Syndrome (blood clotting disease caused by e. coli infection, birth control pills, pneumonia, medications, and more): 16 people, 15.38%
Graft Versus Host Disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body): 16 people, 15.38%
Thrombocytopenia (decrease of platelets in blood): 13 people, 12.50%
Renal Impairment (severely reduced kidney function): 12 people, 11.54%
Blood Lactate Dehydrogenase Increased: 12 people, 11.54%
Fever: 11 people, 10.58%
Acute Kidney Failure: 8 people, 7.69%
Ards (Acute Respiratory Distress Syndrome) (sudden failure of the respiratory (breathing) system): 8 people, 7.69%
Disseminated Intravascular Coagulation (systemic activation of blood coagulation): 8 people, 7.69%
Blood Creatinine Increased: 8 people, 7.69%

What are the existing conditions these people have? *

Constipation: 6 people, 5.77%
Insomnia (sleeplessness): 5 people, 4.81%
Gastritis (inflammation of stomach): 5 people, 4.81%
Stress And Anxiety: 5 people, 4.81%
Hyperlipidaemia (presence of excess lipids in the blood): 5 people, 4.81%
Osteoporosis (bones weak and more likely to break): 5 people, 4.81%
Graft Versus Host Disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body): 5 people, 4.81%
Peripheral T-Cell Lymphoma Unspecified (peripheral t-cell cancer unspecified): 4 people, 3.85%
Pneumocystis Jiroveci Pneumonia (fungal infection of the lungs): 4 people, 3.85%
Acute Lymphocytic Leukemia (All) (cancer of the white blood cells characterized by excess lymphoblasts): 4 people, 3.85%

* Approximation only. Some reports may have incomplete information.

Do you take Methotrexate and have Ttp?

- Check whether Ttp is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Methotrexate:

Methotrexate (604,298 reports)

Ttp treatments and more:

Ttp (6,447 reports)

Browse all side effects of Methotrexate:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Common drugs associated with Ttp:

Browse all the drugs that are associated with Ttp:

Ttp (987 drugs)

Common conditions associated with Ttp:

Hypertension: 208 reports
High blood pressure: 207 reports
Plasma cell myeloma: 186 reports
Preventive health care: 109 reports
Multiple sclerosis aggravated: 107 reports
Drug-eluting stents: 103 reports

Browse all the conditions that are associated with Ttp:

Ttp (819 conditions)

Drugs similar to Methotrexate and Ttp :

Related publications that referenced our studies

Henien M, Carey B, Hullah E, Sproat C, Patel V, "methotrexate-associated osteonecrosis of the jaw: A report of two cases", Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 2017 Dec .
Henien M, Carey B, Hullah E, Sproat C, Patel V, "methotrexate-associated osteonecrosis of the jaw: A report of two cases", Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 2017 Dec .

How the study uses the data?

The study uses data from the FDA. It is based on methotrexate sodium (the active ingredients of Methotrexate) and Methotrexate (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.