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Methyldopa and Hypertensive crisis - a phase IV clinical study of FDA data

Summary:

Hypertensive crisis is reported as a side effect among people who take Methyldopa (methyldopa), especially for people who are female, 30-39 old, have been taking the drug for 1 - 6 months also take Nifedipine, and have Gestational diabetes.

The phase IV clinical study analyzes which people have Hypertensive crisis when taking Methyldopa. It is created by eHealthMe based on reports of 6,345 people who have side effects when taking Methyldopa from the FDA, and is updated regularly.

What is Methyldopa?

Methyldopa has active ingredients of methyldopa. It is often used in high blood pressure. eHealthMe is studying from 6,475 Methyldopa users. Check the latest studies of Methyldopa.

What is Hypertensive crisis?

Hypertensive crisis is found to be associated with 787 drugs and 931 conditions by eHealthMe. Check the latest studies of Hypertensive crisis.

On Jul, 26, 2026

6,345 people reported to have side effects when taking Methyldopa.
Among them, 40 people (0.63%) have Hypertensive crisis.

Could Methyldopa cause Hypertensive crisis?

Among these 40 people:

How long have people been on Methyldopa when they have Hypertensive crisis? *

  • < 1 month: 33.33 %
  • 1 - 6 months: 66.67 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

What is the gender of people who have Hypertensive crisis when taking Methyldopa? *

  • female: 83.33 %
  • male: 16.67 %

What is the age of people who have Hypertensive crisis when taking Methyldopa? *

  • 0-1: 14.71 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 5.88 %
  • 30-39: 29.41 %
  • 40-49: 0.0 %
  • 50-59: 26.47 %
  • 60+: 23.53 %

What are other drugs people take besides Methyldopa? *

  1. Nifedipine: 7 people, 17.50%
  2. Metoclopramide: 4 people, 10.00%
  3. Hydrochlorothiazide: 4 people, 10.00%
  4. Norvasc: 3 people, 7.50%
  5. Amlodipine: 3 people, 7.50%
  6. Contac 12 Hour: 3 people, 7.50%
  7. Potassium Chloride: 3 people, 7.50%
  8. Magnesium Sulfate: 3 people, 7.50%
  9. Atenolol: 3 people, 7.50%
  10. Gentamicin: 2 people, 5.00%

What are other side effects people have besides Hypertensive crisis? *

  1. Headache (pain in head): 6 people, 15.00%
  2. Arrhythmias (irregular heartbeat): 6 people, 15.00%
  3. Maternal Exposure During Pregnancy (use of substance during pregnancy): 6 people, 15.00%
  4. Foetal Exposure During Pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect): 5 people, 12.50%
  5. Drug Withdrawal Syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation): 4 people, 10.00%
  6. Drug Ineffective: 3 people, 7.50%
  7. Haemorrhagic Stroke (stroke caused by the rupture of a blood vessel in the brain): 3 people, 7.50%
  8. Electrocardiogram T Wave Abnormal: 3 people, 7.50%
  9. Hypokalemia (low potassium): 3 people, 7.50%
  10. Weakness: 3 people, 7.50%

What are the existing conditions these people have? *

  1. Gestational Hypertension (elevated blood pressure during pregnancy): 4 people, 10.00%
  2. Gestational Diabetes (diabetes in pregnancy): 4 people, 10.00%
  3. Nausea (feeling of having an urge to vomit): 3 people, 7.50%
  4. Indigestion: 3 people, 7.50%
  5. Hypokalemia (low potassium): 2 people, 5.00%
  6. Renal Cell Carcinoma (a kidney cancer): 2 people, 5.00%
  7. Mouth Injury: 2 people, 5.00%
  8. High Blood Cholesterol: 2 people, 5.00%
  9. Haemolytic Uraemic Syndrome (blood clotting disease caused by e. coli infection, birth control pills, pneumonia, medications, and more): 2 people, 5.00%
  10. Depression: 1 person, 2.50%

* Approximation only. Some reports may have incomplete information.

Do you take Methyldopa and have Hypertensive crisis?

- Check whether Hypertensive crisis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Methyldopa:

Hypertensive crisis treatments and more:

How severe was Hypertensive crisis and when was it recovered:

Expand to all the drugs that have ingredients of methyldopa:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Methyldopa:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hypertensive crisis:

Browse all the conditions that are associated with Hypertensive crisis:

How the study uses the data?

The study uses data from the FDA. It is based on methyldopa (the active ingredients of Methyldopa) and Methyldopa (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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