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Methylphenidate hydrochloride and Akathisia - a phase IV clinical study of FDA data

Summary:

Akathisia is reported as a side effect among people who take Methylphenidate hydrochloride (methylphenidate hydrochloride), especially for people who are male, 20-29 old, have been taking the drug for < 1 month also take Ondansetron, and have Stress and anxiety.

The phase IV clinical study analyzes which people have Akathisia when taking Methylphenidate hydrochloride. It is created by eHealthMe based on reports of 6,364 people who have side effects when taking Methylphenidate hydrochloride from the FDA, and is updated regularly.

What is Methylphenidate hydrochloride?

Methylphenidate hydrochloride has active ingredients of methylphenidate hydrochloride. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 6,823 Methylphenidate hydrochloride users. Check the latest studies of Methylphenidate hydrochloride.

What is Akathisia?

Akathisia (a movement disorder characterized by a feeling of inner restlessness) is found to be associated with 441 drugs and 825 conditions by eHealthMe. Check the latest studies of Akathisia.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 20, 2026

6,364 people reported to have side effects when taking Methylphenidate hydrochloride.
Among them, 20 people (0.31%) have Akathisia.

Could Methylphenidate hydrochloride cause Akathisia?

Among these 20 people:

How long have people been on Methylphenidate hydrochloride when they have Akathisia? *

  • < 1 month: 100 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

What is the gender of people who have Akathisia when taking Methylphenidate hydrochloride? *

  • female: 35.29 %
  • male: 64.71 %

What is the age of people who have Akathisia when taking Methylphenidate hydrochloride? *

  • 0-1: 0.0 %
  • 2-9: 5.88 %
  • 10-19: 17.65 %
  • 20-29: 47.06 %
  • 30-39: 0.0 %
  • 40-49: 29.41 %
  • 50-59: 0.0 %
  • 60+: 0.0 %

What are other drugs people take besides Methylphenidate hydrochloride? *

  1. Sertraline: 5 people, 25.00%
  2. Ondansetron: 5 people, 25.00%
  3. Fentanyl Citrate: 3 people, 15.00%
  4. Invega Sustenna: 2 people, 10.00%
  5. Fentanyl: 2 people, 10.00%
  6. Cannabis: 2 people, 10.00%
  7. Melatonin: 1 person, 5.00%
  8. Lisdexamfetamine Dimesylate: 1 person, 5.00%

What are other side effects people have besides Akathisia? *

  1. Agitation (state of anxiety or nervous excitement): 12 people, 60.00%
  2. Serotonin Syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time): 10 people, 50.00%
  3. Insomnia (sleeplessness): 7 people, 35.00%
  4. Nausea (feeling of having an urge to vomit): 6 people, 30.00%
  5. Arrhythmias (irregular heartbeat): 6 people, 30.00%
  6. Tachyphrenia (abnormally rapid mental activity): 6 people, 30.00%
  7. Delirium (wild excitement): 5 people, 25.00%
  8. Hyperhidrosis (abnormally increased sweating): 5 people, 25.00%
  9. High Blood Pressure: 5 people, 25.00%
  10. Major Depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings): 5 people, 25.00%

What are the existing conditions these people have? *

  1. Stress And Anxiety: 7 people, 35.00%
  2. Depression: 6 people, 30.00%
  3. Birth Control: 5 people, 25.00%
  4. General Anaesthesia: 4 people, 20.00%
  5. Bipolar Disorder (mood disorder): 4 people, 20.00%
  6. Aggression: 3 people, 15.00%
  7. Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 2 people, 10.00%
  8. Psychotic Disorder: 2 people, 10.00%
  9. Panic Disorder: 2 people, 10.00%
  10. Insomnia (sleeplessness): 2 people, 10.00%

* Approximation only. Some reports may have incomplete information.

Do you take Methylphenidate hydrochloride and have Akathisia?

- Check whether Akathisia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Methylphenidate hydrochloride:

Akathisia treatments and more:

How severe was Akathisia and when was it recovered:

Expand to all the drugs that have ingredients of methylphenidate hydrochloride:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Methylphenidate hydrochloride:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Akathisia:

Browse all the conditions that are associated with Akathisia:

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on methylphenidate hydrochloride (the active ingredients of Methylphenidate hydrochloride) and Methylphenidate hydrochloride (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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