Methylphenidate hydrochloride and Fluid retention - a phase IV clinical study of FDA data

Summary:

Fluid retention is reported as a side effect among people who take Methylphenidate hydrochloride (methylphenidate hydrochloride), especially for people who are female, 20-29 old, have been taking the drug for < 1 month also take Vyvanse, and have Cataplexy.

The phase IV clinical study analyzes which people have Fluid retention when taking Methylphenidate hydrochloride. It is created by eHealthMe based on reports of 6,364 people who have side effects when taking Methylphenidate hydrochloride from the FDA, and is updated regularly.

What is Methylphenidate hydrochloride?

Methylphenidate hydrochloride has active ingredients of methylphenidate hydrochloride. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 6,822 Methylphenidate hydrochloride users. Check the latest studies of Methylphenidate hydrochloride.

What is Fluid retention?

Fluid retention (an abnormal accumulation of fluid in the blood) is found to be associated with 1,702 drugs and 2,444 conditions by eHealthMe. Check the latest studies of Fluid retention.

On Jul, 19, 2026

6,364 people reported to have side effects when taking Methylphenidate hydrochloride.
Among them, 39 people (0.61%) have Fluid retention.

Could Methylphenidate hydrochloride cause Fluid retention?

Among these 39 people:

How long have people been on Methylphenidate hydrochloride when they have Fluid retention? *

What is the gender of people who have Fluid retention when taking Methylphenidate hydrochloride? *

female: 78.12 %
male: 21.88 %

What is the age of people who have Fluid retention when taking Methylphenidate hydrochloride? *

What are other drugs people take besides Methylphenidate hydrochloride? *

What are other side effects people have besides Fluid retention? *

Drowsiness: 27 people, 69.23%
Disturbance In Attention: 25 people, 64.10%
Acne (skin problems that cause pimples): 24 people, 61.54%
Drug Intolerance (drug sensitivity): 24 people, 61.54%
Drug Ineffective: 24 people, 61.54%
Dyspnea (difficult or laboured breathing): 10 people, 25.64%
Gastrointestinal Disorder (functional problems of gastrointestinal tract): 7 people, 17.95%
Orthostatic Hypertension (a medical condition consisting of a sudden increase in blood pressure when a person stands up): 7 people, 17.95%
Loss Of Consciousness: 7 people, 17.95%
Diarrhea: 7 people, 17.95%

What are the existing conditions these people have? *

Cataplexy (loss of muscle tone accompanied by full conscious awareness): 14 people, 35.90%
Torticollis (a twisted neck in which the head is tipped to one side, while the chin is turned to the other): 7 people, 17.95%
Spinal Pain (pain in spine): 7 people, 17.95%
Rapid Eye Movements Sleep Abnormal: 7 people, 17.95%
Pain: 7 people, 17.95%
Nausea (feeling of having an urge to vomit): 7 people, 17.95%
Migraine (headache): 7 people, 17.95%
Impaired Gastric Emptying: 7 people, 17.95%
High Blood Cholesterol: 7 people, 17.95%
Dysmenorrhea (painful menstruation): 7 people, 17.95%

* Approximation only. Some reports may have incomplete information.

Do you take Methylphenidate hydrochloride and have Fluid retention?

- Check whether Fluid retention is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Methylphenidate hydrochloride:

Methylphenidate hydrochloride (6,822 reports)

Fluid retention treatments and more:

Fluid retention (79,660 reports)

Browse all side effects of Methylphenidate hydrochloride:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Fluid retention:

Fluid retention (1,702 drugs)

Browse all the conditions that are associated with Fluid retention:

Fluid retention (2,444 conditions)

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on methylphenidate hydrochloride (the active ingredients of Methylphenidate hydrochloride) and Methylphenidate hydrochloride (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.