Methylphenidate hydrochloride and Respiratory depression - a phase IV clinical study of FDA data

Summary:

Respiratory depression is reported as a side effect among people who take Methylphenidate hydrochloride (methylphenidate hydrochloride), especially for people who are male, 30-39 old, have been taking the drug for < 1 month also take Amisulpride, and have Cataplexy.

The phase IV clinical study analyzes which people have Respiratory depression when taking Methylphenidate hydrochloride. It is created by eHealthMe based on reports of 6,364 people who have side effects when taking Methylphenidate hydrochloride from the FDA, and is updated regularly.

What is Methylphenidate hydrochloride?

Methylphenidate hydrochloride has active ingredients of methylphenidate hydrochloride. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 6,823 Methylphenidate hydrochloride users. Check the latest studies of Methylphenidate hydrochloride.

What is Respiratory depression?

Respiratory depression (respiration has a rate below 12 breaths) is found to be associated with 709 drugs and 838 conditions by eHealthMe. Check the latest studies of Respiratory depression.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 30, 2026

6,364 people reported to have side effects when taking Methylphenidate hydrochloride.
Among them, 15 people (0.24%) have Respiratory depression.

Could Methylphenidate hydrochloride cause Respiratory depression?

Among these 15 people:

How long have people been on Methylphenidate hydrochloride when they have Respiratory depression? *

What is the gender of people who have Respiratory depression when taking Methylphenidate hydrochloride? *

female: 21.43 %
male: 78.57 %

What is the age of people who have Respiratory depression when taking Methylphenidate hydrochloride? *

What are other drugs people take besides Methylphenidate hydrochloride? *

What are other side effects people have besides Respiratory depression? *

Drug Abuse: 10 people, 66.67%
Drug Dependence: 8 people, 53.33%
Consciousness - Decreased: 6 people, 40.00%
Agitation (state of anxiety or nervous excitement): 4 people, 26.67%
Overdose: 3 people, 20.00%
Suicide Attempt: 3 people, 20.00%
Hypotension (abnormally low blood pressure): 3 people, 20.00%
Deep Venous Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 2 people, 13.33%
Muscle Spasticity (tight or stiff muscles and an inability to control those muscles): 2 people, 13.33%
Constipation: 2 people, 13.33%

What are the existing conditions these people have? *

Cataplexy (loss of muscle tone accompanied by full conscious awareness): 2 people, 13.33%
Personality Disorder: 1 person, 6.67%
Drowsiness: 1 person, 6.67%
Asthma: 1 person, 6.67%

* Approximation only. Some reports may have incomplete information.

Do you take Methylphenidate hydrochloride and have Respiratory depression?

- Check whether Respiratory depression is associated with a drug or a condition
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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Methylphenidate hydrochloride:

Methylphenidate hydrochloride (6,823 reports)

Browse all side effects of Methylphenidate hydrochloride:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Respiratory depression:

Respiratory depression (709 drugs)

Browse all the conditions that are associated with Respiratory depression:

Respiratory depression (838 conditions)

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on methylphenidate hydrochloride (the active ingredients of Methylphenidate hydrochloride) and Methylphenidate hydrochloride (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.